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. 2023 Aug 31;23(1):318.
doi: 10.1186/s12890-023-02606-1.

Association between chronic obstructive pulmonary disease and cardiovascular disease in adults aged 40 years and above: data from NHANES 2013-2018

Hong Chen  1 , Xiaojia Luo  2 , Yuejun Du  3 , Chenyun He  4 , Yanjun Lu  4 , Zixuan Shi  3 , Jin Zhou  5
Affiliations

Association between chronic obstructive pulmonary disease and cardiovascular disease in adults aged 40 years and above: data from NHANES 2013-2018

Hong Chen et al. BMC Pulm Med. .

Abstract

Background: Chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD) are two major age-related diseases prevalent in the elderly. However, it is unclear whether there is a higher prevalence of one or more CVDs in COPD patients compared to those without COPD, and the magnitude of this increased prevalence.

Methods: This population-based cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018 among American adults aged 40 years and above. Multivariable logistic regression models (including unadjusted model, minimally adjusted model, and fully adjusted model) were conducted to investigate the association between COPD and the prevalence of one or more CVDs, including coronary heart disease, heart failure, angina pectoris, heart attack, diabetes, and stroke.

Results: This study included 11,425 participants, consisting of 661 participants with COPD and 10,764 participants without COPD. COPD patients had a significantly higher prevalence of CVD than those without COPD (59.6% vs. 28.4%). After adjusting for covariates, COPD was significantly associated with the prevalence of one CVD (OR = 2.2, 95% CI = 1.6-3.0, p < 0.001), two or more CVDs (OR = 3.3, 95% CI = 2.2-5.0, p < 0.001), and three or more CVDs (OR = 4.3, 95% CI = 2.9-6.5, p < 0.001).

Conclusions: Patients with COPD have a higher prevalence of one or more CVDs compared with those without COPD. Our findings highlight the importance of CVD prevention and management in patients with COPD.

Keywords: Aging; Cardiovascular disease (CVD); Chronic obstructive pulmonary disease (COPD); NHANES.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of patient selection from the NHANES 2013–2018. NHANES, National Health and Nutrition Examination Survey; COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease
Fig. 2
Fig. 2
Prevalence of CVD in COPD and control groups. COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease
Fig. 3
Fig. 3
Association between COPD and prevalence of CVD in adults aged 40 years and above. A, Unadjusted model: with no covariate adjustment; B, Minimally adjusted model: with adjustment of age, gender, and race; C, Fully adjusted model: with adjustment of age, gender, race, body mass index, smoking status, education level, annual family income, blood eosinophil counts, and comorbidities, including asthma, chronic bronchitis, and emphysema. COPD, chronic obstructive pulmonary disease; CVD, cardiovascular disease; OR, odds ratio; CI, confidence interval
See this image and copyright information in PMC

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