Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug 31;22(1):140.
doi: 10.1186/s12944-023-01908-x.

A cross-sectional study exploring the relationship between the dietary inflammatory index and hyperlipidemia based on the National Health and Nutrition Examination Survey (2005-2018)

Yu Han  1 , Xijuan Jiang  1 , Yabin Qin  1 , Yile Zhao  1 , Guying Zhang  2 , Chao Liu  3   4   5
Affiliations

A cross-sectional study exploring the relationship between the dietary inflammatory index and hyperlipidemia based on the National Health and Nutrition Examination Survey (2005-2018)

Yu Han et al. Lipids Health Dis. .

Erratum in

Abstract

Background: Hyperlipidemia is closely associated with dietary patterns and inflammation. However, the relationship between hyperlipidemia and the inflammatory potential of diets remains unexplored. The research was conducted to examine the relationship between hyperlipidemia and dietary inflammatory index (DII).

Methods: The data utilized in the research were acquired from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. The information on dietary intake was gathered by conducting 24-h dietary recall interviews. Restricted cubic spline (RCS) and Survey-weighted logistic regression were utilized to determine the association between DII and hyperlipidemia. Furthermore, stratification analysis was carried out.

Results: This study included 8982 individuals with and 3458 without hyperlipidemia. Participants with hyperlipidemia exhibited higher DII scores than those without hyperlipidemia. Following adjustment for gender, age, race, education level, marital status, poverty, drinking status, diabetes, hypertension, smoking status, body mass index (BMI), chronic kidney disease (CKD), cardiovascular disease (CVD), and hemoglobin (Hb), the association between the prevalence of hyperlipidemia and DII remained significant. The RCS data demonstrated that the hyperlipidemia prevalence did not exhibit an increase until the DII score was approximately 2.78. Stratification analysis revealed that the association between DII and hyperlipidemia persisted in all subgroups.

Conclusions: DII was associated with hyperlipidemia, and the threshold DII score for the risk of hyperlipidemia was 2.78.

Keywords: Diet; Dietary inflammatory index; Hyperlipidemia; Inflammation; National Health and Nutrition.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of the study subjects
Fig. 2
Fig. 2
RCS depicts the association between DII and hyperlipidemia The red line represents OR, and the red transparent area represents 95% CI. ORs results are adjusted based on Model 3. (OR, odds ratio; CI, confidence interval)
Fig. 3
Fig. 3
Subgroup analysis of the relationship between DII and hyperlipidemia. The outcome is adjusted for all covariables, with the exception of the corresponding stratification variable, glucose and eGFR
See this image and copyright information in PMC

References

    1. Sudhakaran S, Bottiglieri T, Tecson KM, Kluger AY, McCullough PA. Alteration of lipid metabolism in chronic kidney disease, the role of novel antihyperlipidemic agents, and future directions. Rev Cardiovasc Med. 2018;19(3):77–88. doi: 10.31083/j.rcm.2018.03.908. - DOI - PubMed
    1. Li Z, Zhu G, Chen G, Luo M, Liu X, Chen Z, Qian J. Distribution of lipid levels and prevalence of hyperlipidemia: data from the NHANES 2007–2018. Lipids Health Dis. 2022;21(1):111. doi: 10.1186/s12944-022-01721-y. - DOI - PMC - PubMed
    1. Tsao CF, Chang CM, Weng SW, Wang PW, Lin CY, Lu SN. Identifying endemic areas and estimating the prevalence of hyperlipidemia in Taiwan's townships. J Formos Med Assoc. 2021;120(1 Pt 2):460–465. doi: 10.1016/j.jfma.2020.05.031. - DOI - PubMed
    1. Ma Y, Wang W, Zhang J, Lu Y, Wu W, Yan H, Wang Y. Hyperlipidemia and atherosclerotic lesion development in Ldlr-deficient mice on a long-term high-fat diet. PLoS One. 2012;7(4):e35835. doi: 10.1371/journal.pone.0035835. - DOI - PMC - PubMed
    1. Estruch R, Martínez-González MA, Corella D, Basora-Gallisá J, Ruiz-Gutiérrez V, Covas MI, Fiol M, Gómez-Gracia E, López-Sabater MC, Escoda R, Pena MA, Diez-Espino J, Lahoz C, Lapetra J, Sáez G, Ros E. PREDIMED Study Investigators. Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk. J Epidemiol Community Health. 2009;63(7):582–8. doi: 10.1136/jech.2008.082214. - DOI - PubMed

LinkOut - more resources