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Meta-Analysis
. 2023 Aug 25;102(34):e34620.
doi: 10.1097/MD.0000000000034620.

Clinical efficacy of low-dose aspirin combined with calcium in preventing preeclampsia: A systematic review and meta-analysis

Wen-Yue Chen  1 , Su-Fang Sun
Affiliations
Meta-Analysis

Clinical efficacy of low-dose aspirin combined with calcium in preventing preeclampsia: A systematic review and meta-analysis

Wen-Yue Chen et al. Medicine (Baltimore). .

Abstract

Objective: This systematic review and meta-analysis aimed to evaluate the clinical effectiveness of low-dose aspirin combined with calcium supplements for the prevention of preeclampsia.

Methods: China National Knowledge Infrastructure, VIP, Wanfang, PubMed, EMBASE, and Cochrane Library databases were searched from inception until December 2022. Randomized controlled trials investigating the preventive use of aspirin in combination with calcium supplementation for preeclampsia in high-risk pregnant women were included. The quality of the literature was evaluated, and a meta-analysis was conducted using RevMan 5.3 software to analyze the clinical efficacy of low-dose aspirin combined with calcium supplementation in preventing preeclampsia.

Results: Seven randomized controlled trials were included in this meta-analysis, and compared with the control group, the experimental group had lower incidence rates of preeclampsia with gestational hypertension (odds ratios [OR]: 0.17, 95% confidence interval [CI]: 0.11-0.28), preeclampsia (OR: 0.20, 95% CI: 0.10-0.37), gestational hypertension (OR: 0.15, 95% CI: 0.07-0.31), preterm birth (OR: 0.26, 95% CI: 0.16-0.44), postpartum hemorrhage (OR: 0.15, 95% CI: 0.08-0.27), and fetal growth restriction (OR: 0.16, 95% CI: 0.08-0.33).

Conclusion: Compared with aspirin alone, low-dose aspirin combined with calcium supplementation was more effective in preventing preeclampsia, reduced the risk of preterm birth and postpartum hemorrhage, and promoted fetal growth. This intervention has clinical value and should be considered for high-risk pregnant women.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flow chart of study selection process.
Figure 2.
Figure 2.
Forest plot of the incidence of preeclampsia with gestational hypertension.
Figure 3.
Figure 3.
Forest plot of the incidence of preeclampsia.
Figure 4.
Figure 4.
Forest plot of the incidence of gestational hypertension.
Figure 5.
Figure 5.
Funnel plots of publication bias of the incidence of preeclampsia and gestational hypertension. (A) Preeclampsia and gestational. (B) Preeclampsia. (C) Gestational hypertension.
Figure 6.
Figure 6.
Forest plot of the incidence of preterm birth.
Figure 7.
Figure 7.
Forest plot of the incidence of postpartum hemorrhage.
Figure 8.
Figure 8.
Forest plot of the incidence of fetal growth restriction.
Figure 9.
Figure 9.
Funnel plots of publication bias of preterm birth, postpartum hemorrhage, and fetal growth restriction. (A) Preterm birth. (B) Postpartum hemorrhage. (C) Fetal growth restriction.
See this image and copyright information in PMC

References

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