Desmoplastic Ameloblastoma-A Case Report

Abstract

Desmoplastic ameloblastoma (DA) is a rare variant of conventional ameloblastoma. It accounts for only 4%-13% of all ameloblastomas. DA was included in the World Health Organization Classification of Head and Neck Tumors (WHO-2005) as a variant of ameloblastoma with specific clinical, imaging, and histological features. The desmoplastic variant of ameloblastoma usually appears in the anterior and premolar regions as a mixed radiolucent and radiopaque lesion, sometimes resembling a benign fibro-osseous lesion.Ameloblastoma is a locally aggressive tumor that may cause recurrence and in rare cases, malignant transformation with repeated postsurgical recurrences. In this paper, we present a case of a 28-year-old female with swelling in the left upper jaw, a biopsy of which turned out to be DA.

Keywords: Ameloblastoma; benign fibro-osseous lesion; desmoplastic ameloblastoma; odontogenic tumor.

Figure 1

CT imaging showing soap bubble appearance with a displacement of 24 and 25

Figure 2

Odontogenic islands surrounded by abundant thick collagen fibers compressing the odontogenic islands (H and E stain)

Figure 3

Odontogenic epithelium with peripherally arranged cuboidal to few columnar cells with hyperchromatic nuclei and centrally placed squamous cells (H and E stain)

Figure 4

Periphery of the stroma showing osseous metaplasia with active osteoblast rimming (H and E stain)