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. 2023 Aug 19:48:101257.
doi: 10.1016/j.ijcha.2023.101257. eCollection 2023 Oct.

Predictors for all-cause mortality in men after transcatheter aortic valve replacement: A report from the LAPLACE-TAVI registry

Kota Nishida  1 , Mike Saji  1   2 , Ryosuke Higuchi  1 , Itaru Takamisawa  1 , Mamoru Nanasato  1 , Harutoshi Tamura  3 , Kei Sato  4 , Hiroaki Yokoyama  5 , Shinichiro Doi  6 , Shinya Okazaki  6 , Takayuki Onishi  7 , Tetsuya Tobaru  7 , Shuichiro Takanashi  8 , Kazuyuki Ozaki  9 , Takayuki Inomata  9 , Mitsuaki Isobe  10
Affiliations

Predictors for all-cause mortality in men after transcatheter aortic valve replacement: A report from the LAPLACE-TAVI registry

Kota Nishida et al. Int J Cardiol Heart Vasc. .

Abstract

Background: Information regarding the outcomes of transcatheter aortic valve replacement (TAVR) in men is limited. This study aimed to investigate short- to mid-term outcomes and prognostic predictors in this population.

Method and results: The data of 519 men were analyzed from 1,693 consecutive patients with symptomatic severe aortic stenosis who underwent TAVR at six hospitals between April 2010 and July 2020. The primary endpoint was all-cause mortality at 30 days after TAVR. The mean age and Society of Thoracic Surgeons (STS) score were 83.7 ± 5.9 years and 6.3 ± 4.7%, respectively. Overall, 23.5% of patients consumed alcohol with a frequency of > 1 drinks/week, and 12.1% consumed alcohol with a frequency of > 8 drinks/week, while 66.1% were former smokers and 4.2% were current smokers. Mortality at 30 days was 0.8%. During the median follow-up period of 448 days, the estimated survival rates at 1 year post-TAVR was 90.7 ± 1.4%. In multivariate analysis, the serum albumin level [hazard ratio (HR): 2.20, 95% confidence interval (CI):1.36-3.62, p = 0.001], atrial fibrillation (HR: 1.79, 95% CI: 1.13-2.82, p = 0.012), and STS score (HR: 1.33, 95% CI: 1.06-1.67, p = 0.015) were independently associated with all-cause mortality following TAVR. Adjusted hazard ratios of current smoking, heavy drinking, and presence of cancer were 1.05 (95% CI: 0.36-2.98),1.37 (95% CI: 0.75-2.48), and 1.13 (95% CI: 0.75-2.48), respectively.

Conclusion: Our study demonstrated that serum albumin levels, atrial fibrillation, and STS score were independently associated with all-cause mortality following TAVR in men.

Keywords: Men; Sex; Transcatheter aortic valve implantation.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Prevalence of drinking habit in men with transcatheter aortic valve replacement The proportion of no-drinkers tended to increase with increasing age group.
Fig. 2
Fig. 2
Prevalence of smoking in men with transcatheter aortic valve replacement. The proportion of never smokers tended to increase with increasing age group.
Fig. 3
Fig. 3
Kaplan–Meier survival curve after transcatheter aortic valve replacement During the median follow-up period of 448 days, the post-TAVR survival rates after 1 and 3 years were 90.7 ± 1.4% and 74.3 ± 2.9%, respectively, as estimated by Kaplan–Meier analysis.
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