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Case Reports
. 2023 Aug 30;15(8):e44375.
doi: 10.7759/cureus.44375. eCollection 2023 Aug.

Probable Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma: A Case Report of a Diagnostic Challenge

Marcela Velarde Loya  1 , Monica G Millan Reza  1 , Mariana Olaya Cordova  1 , Zaira D Chavéz López  2
Affiliations
Case Reports

Probable Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma: A Case Report of a Diagnostic Challenge

Marcela Velarde Loya et al. Cureus. .

Abstract

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma is a rare variety of cutaneous lymphoma. This subtype has an aggressive and quickly progressive clinical course with a survival time of 32 months from the commencement of skin lesions. This article describes a probable case of primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma in a 63-year-old female, which manifested as diffuse non-pruritic erythematous plaques and nodules. The diagnosis of this possible entity was aided by the histopathological and immunohistochemical findings, while immunohistochemistry for T-cell receptor (TCR) gamma/delta could not be done.

Keywords: cd8; cutaneous lymphoma; cytotoxic lymphocytes; epidermotropism; ki67.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Multiple erythematous nodules on the face (A) and abdomen and lower extremities (B). A soft palate ulcer (C).
Figure 2
Figure 2. Focal epidermotropism and dense mononuclear-type proliferation grouped in a band at the papillary and reticular dermis (A). Atypical lymphocyte infiltrate with hyperchromatic nuclei (B).
Figure 3
Figure 3. CD3 (A), CD8 (B), CD4 (C), BCL-2 (D), Ki-67 (E), and granzyme (F) were all positive in the tumor cell population.
CD: cluster of differentiation; BCL-2: B-cell lymphoma 2.
See this image and copyright information in PMC

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