Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep 1;8(9):690-697.
doi: 10.1530/EOR-23-0078.

Mortality, patient-reported outcome measures, and the health economic burden of prosthetic joint infection

Yangqi Xu  1 , Tony B Huang  1 , Michael A Schuetz  2   3   4 , Peter F M Choong  1   5
Affiliations
Review

Mortality, patient-reported outcome measures, and the health economic burden of prosthetic joint infection

Yangqi Xu et al. EFORT Open Rev. .

Abstract

Prosthetic joint infection (PJI) is one of the most devastating complications for a patient following arthroplasty. This scoping review aims to evaluate the burden of PJI on individual patients and the healthcare system regarding the mortality rate, patient-reported quality of life, and healthcare resource utilisation. Patients with PJI have up to a five-fold higher mortality rate than those who have undergone an uninfected primary arthroplasty. There is an increased use of ambulatory aids and reduced joint function scores in patients with PJI. Global quality of life is poorer, specifically measured by the EQ-5D. Direct hospitalisation costs are two- to five-fold higher, attributed to surgery and prostheses, antibiotics, and a prolonged inpatient stay. There is an immense clinical and health economic burden secondary to PJI worldwide. This is expected to rise exponentially due to the increasing number of primary procedures and an ageing population with comorbidities Improving preventative and treatment strategies is imperative for patients and the healthcare system.

Keywords: arthroplasty; health economic; patient-reported outcome measure; prosthetic joint infection.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Figures

Figure 1
Figure 1
PRIMSA flow chart.
See this image and copyright information in PMC

References

    1. Li C Renz N & Trampuz A. Management of periprosthetic joint infection. Hip Pelvis 201830138–146. ( 10.5371/hp.2018.30.3.138) - DOI - PMC - PubMed
    1. Peel TN Cheng AC Lorenzo YP Kong DCM Buising KL & Choong PFM. Factors influencing the cost of prosthetic joint infection treatment. Journal of Hospital Infection 201385213–219. ( 10.1016/j.jhin.2013.07.012) - DOI - PubMed
    1. Wildeman P Rolfson O Soderquist B Wretenberg P & Lindgren V. What are the long-term outcomes of mortality, quality of life, and hip function after prosthetic joint infection of the hip? A 10-year Follow-up from Sweden. Clinical Orthopaedics and Related Research 20214792203–2213. ( 10.1097/CORR.0000000000001838) - DOI - PMC - PubMed
    1. Helwig P Morlock J Oberst M Hauschild O Hubner J Borde J Sudkamp NP & Konstantinidis L. Periprosthetic joint infection: effect on quality of life. International Orthopaedics 2014381077–1081. ( 10.1007/s00264-013-2265-y) - DOI - PMC - PubMed
    1. Walter N Rupp M Hierl K Koch M Kerschbaum M Worlicek M & Alt V. Long-term patient-related quality of life after knee periprosthetic joint infection. Journal of Clinical Medicine 2021101–9. ( 10.3390/jcm10050907) - DOI - PMC - PubMed

LinkOut - more resources