Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Nov 1;29(21):4317-4319.
doi: 10.1158/1078-0432.CCR-23-1700.

Empower the Potential of Trastuzumab Deruxtecan with Novel Combinations

Christian Rolfo  1 , Marzia Del Re  1   2 , Alessandro Russo  3
Affiliations
Comment

Empower the Potential of Trastuzumab Deruxtecan with Novel Combinations

Christian Rolfo et al. Clin Cancer Res. .

Abstract

Trastuzumab deruxtecan (T-DXd) is reshaping the therapeutic landscape of HER2-positive tumors. A recent article reports on the preclinical activity of the combination of T-DXd plus adavosertib, WEE1 kinase inhibitor, which promises to expand the use of this antibody-drug conjugate in HER2-positive tumors with CCNE1 coamplification. See related article by DiPeri et al., p. 4385.

PubMed Disclaimer

Comment on

MeSH terms