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. 2024 Jan 8;193(1):227-231.
doi: 10.1093/aje/kwad179.

CHALLENGES IN ESTIMATING THE EFFECTIVENESS OF 2 DOSES OF COVID-19 VACCINE BEYOND 6 MONTHS IN ENGLAND

Elsie M F Horne, William J Hulme, Ruth H Keogh, Tom M Palmer, Elizabeth J Williamson, Edward P K Parker, Venexia M Walker, Rochelle Knight, Yinghui Wei, Kurt Taylor, Louis Fisher, Jessica Morley, Amir Mehrkar, Iain Dillingham, Sebastian Bacon, Ben Goldacre, Jonathan A C Sterne, For The OpenSAFELY Collaborative

CHALLENGES IN ESTIMATING THE EFFECTIVENESS OF 2 DOSES OF COVID-19 VACCINE BEYOND 6 MONTHS IN ENGLAND

Elsie M F Horne et al. Am J Epidemiol. .
No abstract available

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Figures

Figure 1
Figure 1
Cumulative incidence of a third dose of coronavirus disease 2019 (COVID-19) vaccine (A) and hazard ratios (HRs) for receipt of BNT162b2 (Pfizer-BioNTech) or ChAdOx1 (AstraZeneca) vaccine versus no vaccine (B) in England, 2020–2021. A) Cumulative incidence of receipt of a third dose in the vaccinated groups and receipt of a first dose in the unvaccinated groups throughout follow-up. Cumulative incidence curves are dashed before the Omicron variant became dominant and solid after it became dominant. B) HRs for BNT162b2 versus unvaccinated individuals and ChAdOx1 versus unvaccinated individuals. Circles are hollow before the Omicron variant became dominant and solid after it became dominant. HRs on the y-axes and estimated vaccine effectiveness are presented on the log scale. Each plot’s background is shaded where the cumulative incidence of receipt of a third dose was greater than 80%. Bars show 95% confidence intervals. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
See this image and copyright information in PMC

References

    1. Horne EMF, Hulme WJ, Keogh RH, et al. Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records. BMJ. 2022;378:e071249. - PMC - PubMed
    1. UK Health Security Agency . Chapter 14a. In: COVID-19: The Green Book. London, United Kingdom: UK Health Security Agency; 2020. https://www.gov.uk/government/publications/covid-19-the-green-book-chapt.... Updated September 4, 2023. Accessed October 20, 2021.
    1. NHS England . NHS begins COVID-19 booster vaccination campaign. https://www.england.nhs.uk/2021/09/nhs-begins-covid-19-booster-vaccinati.... Published September 16, 2021. Accessed March 9, 2022.
    1. NHS England . NHS to roll out life-saving booster jab to people aged 30-plus. https://www.england.nhs.uk/2021/12/nhs-to-roll-out-life-saving-booster-j.... Published December 12, 2021. Accessed March 9, 2022.
    1. NHS England . People 40 and over to get their lifesaving booster jab three months on from second dose. https://www.england.nhs.uk/2021/12/people-40-and-over-to-get-their-lifes.... Published December 8, 2021. Accessed March 9, 2022.

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