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Comment
. 2023 Aug 31;186(18):3753-3755.
doi: 10.1016/j.cell.2023.07.033.

Haunting innate immune memories of COVID-19

Birgit Sawitzki  1
Affiliations
Free article
Comment

Haunting innate immune memories of COVID-19

Birgit Sawitzki. Cell. .
Free article

Abstract

In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections via IL-6 induce persistent epigenetic signatures in hemopoietic stem cells and their myeloid progenitors associated with increased inflammatory potential.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
    Cheong JG, Ravishankar A, Sharma S, Parkhurst CN, Grassmann SA, Wingert CK, Laurent P, Ma S, Paddock L, Miranda IC, Karakaslar EO, Nehar-Belaid D, Thibodeau A, Bale MJ, Kartha VK, Yee JK, Mays MY, Jiang C, Daman AW, Martinez de Paz A, Ahimovic D, Ramos V, Lercher A, Nielsen E, Alvarez-Mulett S, Zheng L, Earl A, Yallowitz A, Robbins L, LaFond E, Weidman KL, Racine-Brzostek S, Yang HS, Price DR, Leyre L, Rendeiro AF, Ravichandran H, Kim J, Borczuk AC, Rice CM, Jones RB, Schenck EJ, Kaner RJ, Chadburn A, Zhao Z, Pascual V, Elemento O, Schwartz RE, Buenrostro JD, Niec RE, Barrat FJ, Lief L, Sun JC, Ucar D, Josefowicz SZ. Cheong JG, et al. Cell. 2023 Aug 31;186(18):3882-3902.e24. doi: 10.1016/j.cell.2023.07.019. Epub 2023 Aug 18. Cell. 2023. PMID: 37597510 Free PMC article.

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