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. 2023 Sep 1;13(1):14343.
doi: 10.1038/s41598-023-41411-y.

Small for gestational age and early childhood caries: the BRISA cohort study

Juliana de Kássia Braga Fernandes  1   2 , Francenilde Silva de Sousa  3   4 , Cláudia Maria Coelho Alves  1   5 , Cecília Cláudia Costa Ribeiro  1   5 , Vanda Maria Ferreira Simões  1 , Maria da Conceição Pereira Saraiva  6 , Erika Barbara Abreu Fonseca Thomaz  1   5
Affiliations

Small for gestational age and early childhood caries: the BRISA cohort study

Juliana de Kássia Braga Fernandes et al. Sci Rep. .

Abstract

This study tests the hypothesis that children 12-30 months born small for gestational age (SGA) aged are more susceptible to severe early childhood caries (S-ECC). We used data on 865 children aged 12-30 months from a prospective cohort study conducted in a city in the northeast of Brazil. The study outcome was S-ECC, defined based on the proportion of decayed tooth surfaces (cavitated or not). The main exposure variable was SGA, defined according to the Kramer criterion and the INTERGROWTH-21st standard. Direct (SGA → S-ECC) and indirect effects were estimated using structural equation modeling, calculating standardized factor loadings (SFL) and P-values (alpha = 5%). The final models showed a good fit. SGA influenced S-ECC in the direct and indirect paths. In the group of SGA children with 12 or more erupted teeth defined according to the Kramer criterion, the direct effect was positive (SFL = 0.163; P = 0.019); while among all SGA children defined according to the INTERGROWTH-21st standard, the direct effect was negative (SFL = - 0.711; P < 0.001). Age and number of erupted teeth may influence the occurrence of S-ECC in SGA children, as the number of teeth affects the time of exposure to disease risk factors.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Structural equation modeling of the hypothesis (SGA increases the risk of DDE-mediated S-ECC).
See this image and copyright information in PMC

References

    1. Pitts NB, Baez RJ, Diaz-Guillory C, Donly KJ, Feldens CA, McGrath C. Early childhood caries: IAPD Bangkok declaration. Int. J. Paediatr. Dent. 2019;29(3):384–386. - PubMed
    1. da Silva CHF, Carlos MA, Bento AKM, Gondim GF, Santana GS, Lima KER, da Silva FGO, Nógimo ITA, Martins LFB. Parents’ perception of the quality of life of children seen at a university school clinic. Rev. CPAQV. 2020;12:1.
    1. Boustedt K, Roswall J, Kjellberg E, Twetman S, Dahlgren J. A prospective study of perinatal and metabolic risk factors for early childhood caries. Acta Paediatr. Int. J. Paediatr. 2020;109(11):2356–2361. - PubMed
    1. Lee ACC, Katz J, Blencowe H, Cousens S, Kozuki N, Vogel JP, Adair L, Baqui AH, Bhutta ZA, Calfield LE, et al. National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010. Lancet Glob. Health. 2013;1(1 Suppl):26S–36S. - PMC - PubMed
    1. Costa FS, Silveira ER, Pinto GS, Nascimento GG, Thomson WM, Demarco FF. Developmental defects of enamel and dental caries in the primary dentition: A systematic review and meta-analysis. J. Dent. 2017;60:1–7. - PubMed

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