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. 2023 Sep;13(9):e1404.
doi: 10.1002/ctm2.1404.

Susceptibility gene profiling elucidates the pathogenesis of inflammatory bowel disease and provides precision medicine

Han Gao  1 , Ruize Liu  2 , Hailiang Huang  2 , Zhanju Liu  1
Affiliations

Susceptibility gene profiling elucidates the pathogenesis of inflammatory bowel disease and provides precision medicine

Han Gao et al. Clin Transl Med. 2023 Sep.
No abstract available

Keywords: Chinese population; East Asian; inflammatory bowel disease; personalized medicine; susceptibility gene.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Variance explained for the 16 new IBD EAS loci across EUR and EAS. Index variants in the 16 new IBD EAS loci are plotted. IBD, inflammatory bowel disease; CD, Crohn's disease; UC, ulcerative colitis; EUR, European ancestry; EAS, East Asian ancestry.
FIGURE 2
FIGURE 2
Susceptibility gene profiling benefits to precision and personalized medicine.
See this image and copyright information in PMC

References

    1. de Lange KM, Moutsianas L, Lee JC, et al. Genome‐wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat Genet. 2017;49(2):256‐261. - PMC - PubMed
    1. Collaborators GBDIBD . The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet Gastroenterol Hepatol. 2020;5(1):17‐30. - PMC - PubMed
    1. Liu JZ, van Sommeren S, Huang H, et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 2015;47(9):979‐986. - PMC - PubMed
    1. Brant SR, Okou DT, Simpson CL, et al. Genome‐wide association study identifies african‐specific susceptibility loci in African Americans with inflammatory bowel disease. Gastroenterology. 2017;152(1):206‐217.e2. - PMC - PubMed
    1. Liu Z, Liu R, Gao H, et al. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries. Nat Genet. 2023;55(5):796‐806. - PMC - PubMed

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