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. 2023 Nov;107(3):116053.
doi: 10.1016/j.diagmicrobio.2023.116053. Epub 2023 Aug 9.

miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis

Nashwa El-Khazragy  1 , Noura Mostafa Mohamed  2 , Mohamed Fathalla Mostafa  3 , Mostafa Elnakib  4 , Eman H A Hemida  5 , Amira Salah  6 , Nesma Mohamed Fawzy  6 , Gehan Safwat  7 , Mennatallah M Emam  7 , Nievin Ahmed Mahran  8 , Dina Rabie  3
Affiliations

miRNAs: novel noninvasive biomarkers as diagnostic and prognostic tools in neonatal sepsis

Nashwa El-Khazragy et al. Diagn Microbiol Infect Dis. 2023 Nov.

Abstract

The study aimed to assess the diagnostic and prognostic value of 3 specific microRNAs (miRNAs) in early-onset neonatal sepsis (NS). We examined miR-1, miR-124, and miR-34a in 70 NS patients upon admission and compared them to 70 healthy controls by RT-PCR. The main finding of the study was the difference in miRNA expression levels between NS patients and controls. Higher expression levels of miR-1 and miR-124 were significantly associated with NS, while miR-34a expression was reduced. Among the studied miRNAs, miR-34a exhibited the highest specificity (97%) as a confirmatory test for NS. In the multivariate model, miR-1 and miR-124 were found to be significant predictors of disease progression or mortality. Overall, the study suggests that miR-1, miR-124, and miR-34a could serve as potential biomarkers for diagnosing and predicting outcomes in early-onset NS.

Keywords: miR-1; miR-124; miR-34a; miRNA; mortality; neonatal sepsis.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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