Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug 28:16:3843-3856.
doi: 10.2147/IJGM.S421835. eCollection 2023.

Genetic Variants Associated with Acne Vulgaris

Huan Zhang  1 , Zhengzhong Zhang  1
Affiliations
Review

Genetic Variants Associated with Acne Vulgaris

Huan Zhang et al. Int J Gen Med. .

Abstract

Acne vulgaris (AV) ranks among the common chronic inflammatory disorders that impact the sebaceous components of hair follicles. Acne vulgaris is characterised by cardinal manifestations such as the presence of pimples, nodules, pustules, and cysts, which have the potential to lead to the development of acne scarring and pigmentation. The phenomenon is influenced by polygenic inheritance or can be ascribed to the interplay between multiple genes and environmental factors. In recent years, some researchers have found that some genes (such as IL, TNF, RETN, CYP family, MMPs and TIMPs genes et al) are associated with acne vulgaris and may affect the progression and prognosis of the disease. The number of reviews addressing acne-associated genetic variants, however, is limited. In that case, we have compiled a list of prevalent genes associated with acne in recent times. This helps us understand acne's genetic basis and lets us step in early for people prone to severe acne, lowering the chance of acne scars.

Keywords: acne vulgaris; genetic variants; genetics; susceptible genes.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Similar articles

See all similar articles

Cited by

References

    1. Hazarika N. Acne vulgaris: new evidence in pathogenesis and future modalities of treatment. J Dermatolog Treat. 2021;32(3):277–285. doi: 10.1080/09546634.2019.1654075 - DOI - PubMed
    1. Bernales salinas A. Acne vulgaris: role of the immune system. Int J Dermatol. 2021;60(9):1076–1081. doi: 10.1111/ijd.15415 - DOI - PubMed
    1. Siemens HW. Die Vererbung in der Ätiologie der Hautkrankheiten [Heredity in the etiology of skin diseases]. Berlin Heidelberg: Springer; 1929. German.
    1. Siemens HW. Die Zwillingspathologie: Ihre Bedeutung Ihre Methodik Ihre Bisherigen Ergebnisse [The pathology of twins: its meaning · its methodology · its results so far]; 1924. German.
    1. Bataille V, Snieder H, MacGregor AJ, et al. The influence of genetics and environmental factors in the pathogenesis of acne: a twin study of acne in women. J Invest Dermatol. 2002;119:1317–1322. doi: 10.1046/j.1523-1747.2002.19621.x - DOI - PubMed