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. 2023 Aug 15:10:1095877.
doi: 10.3389/fvets.2023.1095877. eCollection 2023.

Enhancement of protective vaccine-induced antibody titer to swine diseases and growth performance by Amino-Zn, yucca extract, and β-mannanase feed additive in wean-finishing pigs

Vetriselvi Sampath  1 , Sungbo Cho  1 , Byung Ryol Lee  2 , Nam-Hun Kim  2 , In Ho Kim  1
Affiliations

Enhancement of protective vaccine-induced antibody titer to swine diseases and growth performance by Amino-Zn, yucca extract, and β-mannanase feed additive in wean-finishing pigs

Vetriselvi Sampath et al. Front Vet Sci. .

Abstract

The primary purpose of this research is to determine the effect of Amino-Zn (AZn), Yucca schidigera extract (YE), and β-mannanase enzyme supplementation on growth performance, nutrient digestibility, fecal gas emission, and immune response in pigs. A total of 180 crossbred pigs (6.57 ± 1 kg) were randomly assigned to one of three dietary treatments: CON-corn soybean meal (basal diet); TRT1-CON +1,000 ppm AZn + 0.07% yucca extract (YE) + 0.05% β-mannanase; and TRT2-CON +2,000 ppm AZn + 0.07% YE+ 0.05% β-mannanase for 22 weeks. Each treatment had 12 replicates with 5 pigs per pen. Pigs fed a diet supplemented with AZn, YE, and β-mannanase linearly increased (p < 0.05) BW and average daily gain at weeks 6, 12, 17, and 18. In contrast, the gain-to-feed ratio showed a linear increase (p < 0.05) from weeks 6 to 17 and the overall trial period. Moreover, the inclusion of experimental diets linearly decreased (p > 0.05) noxious gas emissions such as ammonia, hydrogen sulfide, acetic acid, carbon dioxide, and methyl mercaptans. The dietary inclusion of AZn, YE, and β-mannanase significantly increased the serological immune responses to Mycoplasma hyopneumoniae (MH) and foot-and-mouth disease virus (FMDV-O type) at the end of week 6 and porcine circovirus-2 (PCV-2) at week 19. Based on this result, we infer that the combination of AZn, YE, and β-mannanase supplement would serve as a novel in-feed additive to enhance growth performance and act as a boosting agent and immune stimulatory to increase the efficacy of swine vaccinations.

Keywords: Amino-Zn; Yucca schidigera extract; antibody; pigs; vaccination; β-mannanase.

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Conflict of interest statement

Authors BRL and NHK were employed by ZinexBio Corporation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic view of the experiment design.
Figure 2
Figure 2
Vaccination and blood collection schedule of pigs from weaning to finishing stage. A total of 180 pigs (12 replicates × 3 treatemet, with 5 pigs/pen) were vaccinated at different periods, and the blood samples were randomly drawn from n = 24/treatment.
Figure 3
Figure 3
Effects of dietary AZn, Yucca schidigera extract, and β-mannanase on growth performance of pigs at different growth stages. Data are presented as standard means of error. *, **, and *** indicate statistically significant at p < 0.05, p < 0.001, and p < 0.0001, respectively.
See this image and copyright information in PMC

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