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Case Reports
. 2023 Aug 18;10(8):ofad438.
doi: 10.1093/ofid/ofad438. eCollection 2023 Aug.

Neuromeningeal Cryptococcosis and Tuberculosis Coinfection in Bamako: A One-Year Case Series

Dramane Ouedraogo  1 , Yacouba Cissoko  1   2 , Mariam Soumare  1 , Amavi Essénam Alle Akakpo  1 , Ouo-Ouo Loua  1 , Issa Konate  1   2 , Safiatou Niare Doumbo  3 , Sounkalo Dao  1   2
Affiliations
Case Reports

Neuromeningeal Cryptococcosis and Tuberculosis Coinfection in Bamako: A One-Year Case Series

Dramane Ouedraogo et al. Open Forum Infect Dis. .

Abstract

Cryptococcosis and tuberculosis are life-threatening opportunistic infections that occur in apparently immunocompetent or severely immunocompromised individuals worldwide. As both infections are strongly linked to HIV infection, they may share certain clinical manifestations, and the interaction of their treatments should be considered. However, despite their similarity, concurrent tuberculosis and cryptococcal infections have rarely been reported in West Africa. Herein, we present 3 cases of neuromeningeal cryptococcosis and lung tuberculosis coinfection collected prospectively over a year at the Department of Infectious Diseases of the Point G Teaching Hospital in Bamako. Two patients had HIV disease, and the third patient had no underlying immunosuppressive illnesses. Thus, active screening for tuberculosis and cryptococcosis, particularly in individuals with HIV, can reduce misdiagnosis and ensure appropriate coinfection management. Moreover, this may reduce mortality due to AIDS-related opportunistic infections in resource-limited settings.

Keywords: HIV; coinfection; cryptococcosis; tuberculosis.

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Conflict of interest statement

Potential conflicts of interest. All authors: no reported conflicts of interest. All authors have completed the ICMJE Form for Disclosure of Potential Conflicts of Interest and declare that there are no conflicts of interest.

References

    1. Gushiken AC, Saharia KK, Baddley JW. Cryptococcosis. Infect Dis Clin North Am 2021; 35:493–514. - PubMed
    1. Rajasingham R, Smith RM, Park BJ, et al. . Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis 2017; 17:873–81. - PMC - PubMed
    1. World Health Organization . Global Tuberculosis Report 2022. World Health Organization; 2022. Available at: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/globa.... Accessed December 22, 2022.
    1. CMIT . Infection par le VIH et Sida. In: ePILLY trop 2022—Maladies Infectieuses Tropicales. 3e ed. Paris: ALINÉA Plus Ed; 2022. p. 610–65.
    1. Huang CT, Tsai YJ, Fan JY, Ku SC, Yu CJ. Cryptococcosis and tuberculosis co-infection at a university hospital in Taiwan, 1993–2006. Infection 2010; 38:373–9. - PubMed

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