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Case Reports
. 2023 Aug 7;85(9):4629-4632.
doi: 10.1097/MS9.0000000000001135. eCollection 2023 Sep.

Clarithromycin-induced acute liver injury in a patient with positive Helicobacter pylori: a case report and review of the literature

Nava Raj Sharma  1 , Abhishesh Wagle  2 , Manoj Bist  3 , Bishal Panthi  1 , Ritu Pokhrel Dahal  4 , Rajesh Rokaya  5 , Rayana Shrestha  2 , Madalasa Pokhrel  6
Affiliations
Case Reports

Clarithromycin-induced acute liver injury in a patient with positive Helicobacter pylori: a case report and review of the literature

Nava Raj Sharma et al. Ann Med Surg (Lond). .

Abstract

Introduction and importance: While 14-day triple therapy with clarithromycin is a common approach for eradicating Helicobacter pylori infection, it is essential to note that this treatment does not come without potential side effects.

Case presentation: We present the case of a 34-year-old male who presented to the emergency department with severe vomiting and abdominal pain. Subsequent evaluation revealed that the patient had developed drug-induced liver injury (DILI).

Clinical discussion: DILI can cause acute hepatocellular or cholestatic damage, and chronic injury can lead to hepatocellular, cholestatic, vascular, or neoplastic manifestations.

Conclusion: Clinicians should exercise caution and be alert to the potential hepatotoxic effects of medications, especially when initiating triple therapy for H. pylori infection.

Keywords: Helicobacter pylori; clarithromycin; drug-induced liver injury.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Ultrasound during admission showing dilated common bile duct measuring 8.5 mm.
Figure 2
Figure 2
Ultrasound after 1 week of admission showing common bile duct measuring 5 mm.
Figure 3
Figure 3
Trend in liver function test.
See this image and copyright information in PMC

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