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Case Reports
. 2023 Aug 1:40:1-3.
doi: 10.1016/j.jdcr.2023.07.024. eCollection 2023 Oct.

Ulcerating necrobiotic xanthogranuloma: A clinical sign to reconsider progression from MGUS to multiple myeloma

Christopher J Fay  1 , Christopher Iriarte  1   2 , Dorsa Moslehi  1   2 , Jimmy Lam  1   2 , Igor Katsyv  3 , Nicole R LeBoeuf  1   2
Affiliations
Case Reports

Ulcerating necrobiotic xanthogranuloma: A clinical sign to reconsider progression from MGUS to multiple myeloma

Christopher J Fay et al. JAAD Case Rep. .
No abstract available

Keywords: MGUS; NXG; monoclonal gammopathy of undetermined significance; multiple myeloma; necrobiotic xanthogranuloma.

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Conflict of interest statement

The authors declare no conflicts of interest with respect to the research, authorship, and/or publication of this article. Nicole R. LeBoeuf is a consultant and has received honoraria from Bayer, Seattle Genetics, Sanofi, Silverback, Fortress Biotech, and Synox Therapeutics outside the scope of the submitted work.

Figures

Fig 1
Fig 1
A,Orange-red plaques with overlying telangiectasias and inflammatory red borders over the abdomen in areas of prior abdominal surgery. B, Enlarging orange-red indurated plaques with central ulceration, overlying crust, and inflammatory red borders over the abdomen. C, Healed orange-red atrophic plaques with central scarring, without evidence of ulceration or inflammation.
Fig 2
Fig 2
A, Granulomatous process with areas of necrobiosis, cholesterol clefts, and giant cells (H&E, 2× magnification). B, Altered (necrobiotic) collagen and cholesterol clefts surrounded by a mixed inflammatory infiltrate with histiocytes and giant cells (H&E, 10× magnification). C, Altered (necrobiotic) collagen and cholesterol clefts with admixed inflammatory infiltrate with histiocytes and giant cells (H&E, 10× magnification).
See this image and copyright information in PMC

References

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