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Review
. 2023 Aug 18:13:1184626.
doi: 10.3389/fonc.2023.1184626. eCollection 2023.

Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

Jing Zhang  1 , Jian Bai  2 , Chen Gong  1 , Jianhua Wang  1 , Yi Cheng  1 , Jing Zhao  1 , Huihua Xiong  1
Affiliations
Review

Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

Jing Zhang et al. Front Oncol. .

Abstract

Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells proliferate more than normal cells and require more serine for proliferation. The cancer-related genes that are involved in serine metabolism also show changes corresponding to metabolic alterations. Here, we reviewed the serine-associated one-carbon metabolism and its potential as a target for anti-tumour therapeutic strategies.

Keywords: SERINE; immunotherapy; metabolism reprogramming; molecular targeted therapy; one-carbon units.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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