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Review
. 2023 Aug 18:13:1184626.
doi: 10.3389/fonc.2023.1184626. eCollection 2023.

Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

Jing Zhang  1 , Jian Bai  2 , Chen Gong  1 , Jianhua Wang  1 , Yi Cheng  1 , Jing Zhao  1 , Huihua Xiong  1
Affiliations
Review

Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy

Jing Zhang et al. Front Oncol. .

Abstract

Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours. Cancer cells proliferate more than normal cells and require more serine for proliferation. The cancer-related genes that are involved in serine metabolism also show changes corresponding to metabolic alterations. Here, we reviewed the serine-associated one-carbon metabolism and its potential as a target for anti-tumour therapeutic strategies.

Keywords: SERINE; immunotherapy; metabolism reprogramming; molecular targeted therapy; one-carbon units.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Li AM, Ye J. Reprogramming of serine, glycine and one-carbon metabolism in cancer. Biochim Biophys Acta Mol Basis Dis (2020) 1866:165841. doi: 10.1016/j.bbadis.2020.165841 - DOI - PMC - PubMed
    1. Pan S, Fan M, Liu Z, Li X, Wang H. Serine, glycine and one−carbon metabolism in cancer (review). Int J Oncol (2021) 58:158–70. doi: 10.3892/ijo.2020.5158 - DOI - PMC - PubMed
    1. Wishart DS. Is cancer a genetic disease or a metabolic disease? Ebiomedicine (2015) 2:478–9. doi: 10.1016/j.ebiom.2015.05.022 - DOI - PMC - PubMed
    1. Newman AC, Maddocks O. One-carbon metabolism in cancer. Br J Cancer (2017) 116:1499–504. doi: 10.1038/bjc.2017.118 - DOI - PMC - PubMed
    1. Ducker GS, Rabinowitz JD. One-carbon metabolism in health and disease. Cell Metab (2017) 25:27–42. doi: 10.1016/j.cmet.2016.08.009 - DOI - PMC - PubMed

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