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Comment
. 2023 Sep 4;8(1):332.
doi: 10.1038/s41392-023-01594-2.

Fumarate hydratase: a new checkpoint of metabolic regulation in inflammatory macrophages

Aicha Jeridi  1 , Theodore S Kapellos  1 , Ali Önder Yildirim  2   3
Affiliations
Comment

Fumarate hydratase: a new checkpoint of metabolic regulation in inflammatory macrophages

Aicha Jeridi et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The function of cellular metabolism and epigenetic regulation in macrophages. In response to environmental trigger bone marrow-derived macrophages undergo changes in their activation and function as a result of epigenetic regulation. Alterations in DNA and histones such as methylation or acetylation have a direct impact on the regulation of gene expression shaping polarization, function and fate of monocytes. Changes in the abundance of metabolites such as TCA intermediates and modification of the DNA or histones are tightly linked. Pro-inflammatory macrophages rely on glycolysis and present disruptions in the TCA cycle resulting in the accumulation of itaconate, succinate and fumarate. Monocyte-derived macrophages exhibit changes in gene expression based on metabolic adaptation leading to the secretion of certain cytokines that have a great impact on disease development and progression such as chronic lung diseases. Created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Macrophage fumarate hydratase restrains mtRNA-mediated interferon production.
    Hooftman A, Peace CG, Ryan DG, Day EA, Yang M, McGettrick AF, Yin M, Montano EN, Huo L, Toller-Kawahisa JE, Zecchini V, Ryan TAJ, Bolado-Carrancio A, Casey AM, Prag HA, Costa ASH, De Los Santos G, Ishimori M, Wallace DJ, Venuturupalli S, Nikitopoulou E, Frizzell N, Johansson C, Von Kriegsheim A, Murphy MP, Jefferies C, Frezza C, O'Neill LAJ. Hooftman A, et al. Nature. 2023 Mar;615(7952):490-498. doi: 10.1038/s41586-023-05720-6. Epub 2023 Mar 8. Nature. 2023. PMID: 36890227 Free PMC article.

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