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Comment
. 2024 Jan;34(1):5-6.
doi: 10.1038/s41422-023-00871-7.

Swiss army knife T cell: one T cell many tumor targets

Abdulla Berjis  1   2 , Deeksha Muthumani  1   2 , Neil C Sheppard  1   3 , Carl H June  4   5
Affiliations
Comment

Swiss army knife T cell: one T cell many tumor targets

Abdulla Berjis et al. Cell Res. 2024 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1. Schematic diagram showing the main findings from Dolton et al.
a Overview of antigen presentation. Proteins get degraded by proteasome into small peptides, and then get loaded into HLA proteins. Once loaded, HLA can leave the ER and get presented on the cell surface. b A CTL cell recognizes a peptide from an abnormal protein through its TCR leading to killing of the target cell. c Overview of the TIL therapy procedure. Tumors are surgically resected, and T cells are isolated, activated and expanded ex vivo prior to infusion into the patient, typically following lymphodepleting chemotherapy, and in combination with subcutaneous IL-2. d A T cell clone such as MEL8 expresses a single TCR that can recognize 3 peptides from 3 different TAAs enhancing T cell recognition and tumor cell destruction.
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