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Meta-Analysis
. 2023 Sep 5;38(1):201.
doi: 10.1007/s10103-023-03864-5.

The effect of the Er,Cr:YSGG laser combined casein phosphopeptide amorphous calcium phosphate for enamel remineralisation: a systematic review and meta-analysis of in vitro studies

Lin Cheng  1   2 , Rui Yuan  3 , Hao Fan  3 , Minmin Si  3 , Zhaonan Hao  3 , Zhiyuan Feng  4   5
Affiliations
Meta-Analysis

The effect of the Er,Cr:YSGG laser combined casein phosphopeptide amorphous calcium phosphate for enamel remineralisation: a systematic review and meta-analysis of in vitro studies

Lin Cheng et al. Lasers Med Sci. .

Abstract

The purpose of this systematic review and meta-analysis of in vitro studies was to evaluate the effect of the 2780 nm Er,Cr:YSGG laser combined with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) for enamel remineralisation. The electronic PubMed, Cochrane Library, Web of Science, and EMBASE databases were searched, with no language or date restrictions, up to January 2023. Two reviewers independently performed research information extraction and quality assessment. Continuous variables were analysed by standard mean difference (SMD) with a 95% confidence interval (CI). The statistical analyses were conducted using Review Manager (Version 5.4; Rev Man) and Cochrane Collaboration (2020). Finally, four trials were included for meta-analysis. According to the comprehensive results, the effect of the Er,Cr:YSGG laser combined with CPP-ACP on enamel remineralisation was significantly better than that of CPP-ACP alone: surface microhardness (SMD = - 1.83, 95% CI: [- 2.98, - 0.69], P = 0.002); lesion depth (SMD = 6.63, 95% CI: [4.98, 8.28], P < 0.001). Under the limitations of this meta-analysis, the results show that the Er,Cr:YSGG laser combined with CPP-ACP has a better effect on enamel remineralisation than CPP-ACP alone. The combination of the Er,Cr:YSGG laser and CPP-ACP may be a feasible method to prevent and treat enamel demineralisation.

Keywords: Casein phosphopeptide-amorphous calcium phosphate; Er,Cr:YSGG laser; Meta-analysis; Remineralisation.

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Conflict of interest statement

The authors declare no competing interests.

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Prisma flow diagram
Fig. 2
Fig. 2
a Judgements about each risk of bias item for each included study. b Judgements about each risk of bias item presented as percentages across all included studies
Fig. 3
Fig. 3
Surface microhardness of CPP-ACP group and laser combined CPP-ACP group
Fig. 4
Fig. 4
Lesion depth of CPP-ACP group and laser combined CPP-ACP group
See this image and copyright information in PMC

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References

    1. Yan J, Yang H, Luo T, Hua F, He H. Application of amorphous calcium phosphate agents in the prevention and treatment of enamel demineralization. Front Bioeng Biotechnol. 2022;10:853436. doi: 10.3389/fbioe.2022.853436. - DOI - PMC - PubMed
    1. Paula AB, Fernandes AR, Coelho AS, Marto CM, Ferreira MM, Caramelo F, do Val F, Carrilho E. Therapies for white spot lesions-a systematic review. J Evid Based Dent Pract. 2017;17(1):23–38. doi: 10.1016/j.jebdp.2016.10.003. - DOI - PubMed
    1. Ogaard B, Rølla G, Arends J. Orthodontic appliances and enamel demineralization. Part 1. Lesion development. Am J Orthod Dentofacial Orthop. 1988;94(1):68–73. doi: 10.1016/0889-5406(88)90453-2. - DOI - PubMed
    1. Kugel G, Arsenault P, Papas A. Treatment modalities for caries management, including a new resin infiltration system. Compend Contin Educ Dent. 2009;3:1–12. - PubMed
    1. Sundararaj D, Venkatachalapathy S, Tandon A, Pereira A. Critical evaluation of incidence and prevalence of white spot lesions during fixed orthodontic appliance treatment: a meta-analysis. J Int Soc Prev Community Dent. 2015;5(6):433–439. doi: 10.4103/2231-0762.167719. - DOI - PMC - PubMed

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