Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Sep;41(8):704-712.
doi: 10.1080/07357907.2023.2255668. Epub 2023 Sep 6.

Intraosseous Spindle Cell Rhabdomyosarcoma with MEIS1:: NCOA2 Fusion - Case Report with Substantial Clinical Follow-up and Review of the Literature

Benjamin F Smith  1 , Yee-Cheen Doung  2 , Brooke Beckett  3 , Christopher L Corless  1   4 , Lara E Davis  5 , Jessica L Davis  6
Affiliations
Review

Intraosseous Spindle Cell Rhabdomyosarcoma with MEIS1:: NCOA2 Fusion - Case Report with Substantial Clinical Follow-up and Review of the Literature

Benjamin F Smith et al. Cancer Invest. 2023 Sep.

Erratum in

  • Correction.
    [No authors listed] [No authors listed] Cancer Invest. 2023 Sep;41(8):750. doi: 10.1080/07357907.2023.2259655. Epub 2023 Oct 31. Cancer Invest. 2023. PMID: 37733418 No abstract available.

Abstract

Spindle cell/sclerosing rhabdomyosarcoma (SSRMS) is a clinicopathologically and molecularly heterogeneous disease. Gene fusions have been identified in intraosseous SSRMS, consisting predominantly of EWSR1/FUS::TFCP2 and MEIS1::NCOA2. The former often follow an aggressive clinical course; there is limited clinical follow-up available for the latter. We report here a new case of the very rare intraosseous SSRMS with MEIS1::NCOA2 gene fusion and include the detailed treatment course and 52 months of clinical follow-up. SSRMS with MEIS1::NCOA2 gene fusion appears biologically distinct from other intraosseous SSRMS, following a course characterized by local recurrence with rare reports of metastasis to date.

Keywords: MEIS1; NCOA2; Rhabdomyosarcoma; bone; gene fusion.

PubMed Disclaimer

LinkOut - more resources