Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct:115:105813.
doi: 10.1016/j.parkreldis.2023.105813. Epub 2023 Aug 19.

Dyskinesia and impulsive compulsive behaviour in Parkinson's disease are not related: Insights from a study with a wearable sensor

Lucia Ricciardi  1 , Andrea De Angelis  2 , Chiara Siri  3 , Malcom Horne  4 , Alison Leake  2 , Dominic Paviour  2 , Priyanka Pradhan  2 , Mark Edwards  5 , Francesca Morgante  6
Affiliations

Dyskinesia and impulsive compulsive behaviour in Parkinson's disease are not related: Insights from a study with a wearable sensor

Lucia Ricciardi et al. Parkinsonism Relat Disord. 2023 Oct.

Abstract

Introduction: Previous studies have suggested an association between Impulsive Compulsive Behaviour (ICB) and dyskinesia in Parkinson's disease (PD). However, none of these studies have employed an objective home-based measure of dyskinesia.

Objectives: To evaluate in advanced PD the relationship between ICB and dyskinesia, objectively measured with a wearable device.

Methods: In this cross-sectional study, ICB and other neuropsychiatric symptoms were assessed by means of structured clinical interview and specific screening instruments. Presence and severity of motor fluctuations and dyskinesia were rated with patient's and clinician's based rating instruments. Motor fluctuations and dyskinesia were also measured at home for 5-days using a validated wearable devise, the Parkinson's KinetiGraph™(PKG).

Results: We included 89 subjects with PD (29 females, 62 ± 7 years, disease duration 10.3 ± 4.5), of whom 36 (40%) had ICB. Patients with and without ICB did not differ by presence and severity of dyskinesia measured by clinical scales and PKG. There was no association between the presence of ICB and dyskinesia in the whole sample.

Conclusion: Our data suggest that ICB and dyskinesia are common but unrelated disorders in advanced PD.

Keywords: Dyskinesia; Impulse control disorders; Impulsive compulsive behaviors; Impulsivity; Parkinson's disease; Wearable sensors.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest This study was supported by Global Kinetics.

Figures

Fig. 1
Fig. 1
There was no difference between PD with and without impulsive compulsive behaviour (ICB) for presence and severity of dyskinesia measured by UPDRS-IV, Unified Dyskinesia Rating Scale (UDRS) and median dyskinesia score (mDKS), obtained by PKG.
See this image and copyright information in PMC

References

    1. Weintraub D., Aarsland D., Chaudhuri K.R., et al. The neuropsychiatry of Parkinson's disease: advances and challenges. Lancet Neurol. 2022;21(1):89–102. doi: 10.1016/S1474-4422(21)00330-6. [published Online First: 2021/12/24] - DOI - PMC - PubMed
    1. Voon V., Napier T.C., Frank M.J., et al. Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update. Lancet Neurol. 2017;16(3):238–250. doi: 10.1016/S1474-4422(17)30004-2. [published Online First: 2017/02/24] - DOI - PubMed
    1. Biundo R., Weis L., Abbruzzese G., et al. Impulse control disorders in advanced Parkinson's disease with dyskinesia: the ALTHEA study. Mov. Disord. 2017;32(11):1557–1565. doi: 10.1002/mds.27181. - DOI - PubMed
    1. Simoni S., Paoletti F.P., Eusebi P., et al. Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: pulsatile versus continuous dopaminergic stimulation. J. Parkinsons Dis. 2020;10(3):927–934. doi: 10.3233/JPD-191833. [published Online First: 2020/04/14] - DOI - PubMed
    1. Postuma R.B., Berg D., Stern M., et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov. Disord. 2015;30(12):1591–1601. - PubMed

Publication types

LinkOut - more resources