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Randomized Controlled Trial
. 2023 Sep 5;23(1):300.
doi: 10.1186/s12871-023-02263-1.

Comparison of the effect of pressure control and volume control ventilation on endotracheal tube cuff pressure in patients undergoing general anesthesia and mechanical ventilation: a parallel randomized clinical trial

Shahram Nasrolahzadeh  1 , Javad Nourian  2 , Ahmad Khosravi  3 , Saeed Ghasempour  4 , Ali Abbasi  5 , Hossein Ebrahimi  6
Affiliations
Randomized Controlled Trial

Comparison of the effect of pressure control and volume control ventilation on endotracheal tube cuff pressure in patients undergoing general anesthesia and mechanical ventilation: a parallel randomized clinical trial

Shahram Nasrolahzadeh et al. BMC Anesthesiol. .

Abstract

Background: Endotracheal intubation and mechanical ventilation are prevalent interventions in the operating room and intensive care unit. Recently, the complications of endotracheal tube cuff pressure have been a topic of interest. Therefore, this study compared the effect of pressure control and volume control ventilation modes on the endotracheal cuff pressure rate in patients undergoing general anesthesia and mechanical ventilation.

Methods: In this triple-blinded randomized clinical trial, 50 patients undergoing open limb surgery and inguinal hernia were allocated to two groups of 25 based on inclusion criteria. After intubation, one group underwent ventilation on the pressure control ventilation mode, and the other underwent ventilation on the volume control ventilation mode. In both groups, using a manometer, the cuff's pressure was first adjusted in the range of 25-30 cm of water. Then, the cuff pressure was measured at 10, 20, and 30 min intervals. The data were statistically analyzed using independent t-test, and two-way repeated measures ANOVA.

Results: The present study's findings showed that cuff pressure has significantly decreased over time in both study groups (F = 117.7, P < 0.001). However, a repeated measures ANOVA with a Greenhouse-Geisser correction showed no interaction between time and groups (F = 0.019, P = 0.98). The two groups had no significant difference in cuff pressure (F = 0.56, P = 0.458).

Conclusion: Since the cuff pressure has been significantly reduced in both groups over time, continuous monitoring of endotracheal tube cuff pressure in patients undergoing mechanical ventilation is essential. Therefore, it is suggested to keep the cuff pressure within the recommended range to prevent complications resulting from cuff pressure reduction, such as aspiration and ventilation decrease.

Trial registration: The study was registered in the Iranian Registry of Clinical Trial on 23/02/2019 (trial registration number: IRCT20181018041376N1).

Keywords: Endotracheal tube cuff pressure; Mechanical ventilation; Pressure control ventilation; Volume control ventilation.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
CONSORT flow diagram
Fig. 2
Fig. 2
Comparison of cuff pressure 10, 20, and 30 min after ventilation in two groups
See this image and copyright information in PMC

References

    1. Henderson J. Airway management in the adult. Miller’s Anaesthesia 7th ed Philadelphia: Churchill Livingstone 2010:1573–1610.
    1. Neto AS, Simonis FD, Barbas CS, Biehl M, Determann RM, Elmer J, Friedman G, Gajic O, Goldstein JN, Linko R. Lung-protective ventilation with low tidal volumes and the occurrence of pulmonary complications in patients without acute respiratory distress syndrome: a systematic review and individual patient data analysis. Crit Care Med. 2015;43(10):2155–63. doi: 10.1097/CCM.0000000000001189. - DOI - PubMed
    1. Sultan P, Carvalho B, Rose BO, Cregg R. Endotracheal tube cuff pressure monitoring: a review of the evidence. J Perioper Pract. 2011;21(11):379–86. - PubMed
    1. Sole ML, Su X, Talbert S, Penoyer DA, Kalita S, Jimenez E, Ludy JE, Bennett M. Evaluation of an intervention to maintain endotracheal tube cuff pressure within therapeutic range. Am J Crit Care. 2011;20(2):109–18. doi: 10.4037/ajcc2011661. - DOI - PMC - PubMed
    1. Godoy ACFd, Vieira RJ, Capitani EMD. Endotracheal tube cuff pressure alteration after changes in position in patients under mechanical ventilation. Jornal Brasileiro de Pneumologia. 2008;34(5):294–7. - PubMed

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