Association of DLT versus SLT with postoperative pneumonia during esophagectomy in China: a retrospective comparison study

Abstract

Background: Double lumen tube (DLT) and single lumen tube (SLT) are two common endotracheal tube (ETT) types in esophageal cancer surgery. Evidence of the relationship between two ETT types and postoperative pneumonia (PP) remains unclear. We aimed to determine the association between two types of ETT (DLT and SLT) and PP and assess the perioperative risk-related parameters that affect PP.

Methods: This study included 680 patients who underwent esophageal cancer surgery from January 01, 2010 through December 31, 2020. The primary outcome was PP, and the secondary outcome was perioperative risk-related parameters that affect PP. The independent variable was the type of ETT: DLT or SLT. The dependent variable was PP. To determine the relationship between variables and PP, univariate and multivariate analyses were performed. The covariables included baseline demographic characteristics, comorbidity disease, neoadjuvant chemotherapy, tumor location, laboratory parameters, intraoperative related variables.

Results: In all patients, the incidence of postoperative pneumonia in esophagectomy was 32.77% (36.90% in DLT group and 26.38% in SLT group). After adjusting for potential risk factors, we found that using an SLT in esophagectomy was associated with lower risk of postoperative pneumonia compared to using a DLT (Odd ratio = 0.41, 95% confidence interval (CI): 0.22, 0.77, p = 0.0057). Besides DLT, smoking history, combined intravenous and inhalation anesthesia (CIIA) and vasoactive drug use were all significant and independent risk factors for postoperative pneumonia in esophagectomy. These results remained stable and reliable after subgroup analysis.

Conclusions: During esophagectomy, there is significant association between the type of ETT (DLT or SLT) and PP. Patients who were intubated with a single lumen tube may have a lower rate of postoperative pneumonia than those who were intubated with a double lumen tube. This finding requires verification in follow-up studies.

Keywords: Double lumen tube; Esophageal cancer; Pneumonia; Postoperative; Single lumen tube.

Fig. 1

Study population flow diagram

Fig. 2

Multivariable logistic regression analysis for the independent effects of male, smoking history, drinking history, pulmonary diseases, TIVA, vasoactive drug use on the risk of postoperative pneumonia. As all VIF values were < 10 (maximal VIF was 4.8), we confirmed the absence of multicollinearity. Abbreviation: adj, adjusted; SLT, single lumen tube; TIVA, total intravenous anesthesia; OR, odds ratio; CI, confidence interval; VIF, variance inflation factor