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. 2023 Sep 5;23(1):579.
doi: 10.1186/s12879-023-08563-8.

Klebsiella pneumoniae bacteraemia epidemiology: resistance profiles and clinical outcome of King Fahad Medical City isolates, Riyadh, Saudi Arabia

Taghreed A Hafiz  1 , Sarah Alanazi  2 , Shahad S Alghamdi  3 , Murad A Mubaraki  2 , Waleed Aljabr  4 , Nouf Madkhali  5 , Sarah R Alharbi  2 , Khalifa Binkhamis  6 , Fawzia Alotaibi  6
Affiliations

Klebsiella pneumoniae bacteraemia epidemiology: resistance profiles and clinical outcome of King Fahad Medical City isolates, Riyadh, Saudi Arabia

Taghreed A Hafiz et al. BMC Infect Dis. .

Abstract

Background and objectives: Klebsiella pneumoniae (K. pneumoniae) is the second leading cause of community-acquired and hospital-acquired gram-negative bloodstream infection (BSI). This study aimed to assess the epidemiological and microbial-resistance characteristics and clinical factors associated with K. pneumoniae BSI in Saudi Arabia.

Materials and methods: Data of 152 K. pneumoniae isolates diagnosed between January 2019 and January 2020 at King Fahad Medical City, Riyadh, Saudi Arabia were evaluated retrospectively. Clinical records of the patients were collected and analysed statistically.

Results: In total, 152 cases of K. pneumoniae BSI were identified. Adult patients (66.4%) were at a higher risk of developing the infection than paediatric patients (33.6%). The rate of infection was slightly higher in women than in men. Neurological disorders were the predominant underlying conditions for the acquisition of K. pneumoniae BSI, at all ages. Most of the deceased patients were adults with multi-organ dysfunction. Klebsiella pneumoniae showed disturbing resistance to amoxicillin-clavulanate and cefuroxime (72.4%), ceftazidime (67.8), cephalothin (76.3%), and to Carbapenems (36.1%).

Conclusions: The impact of K. pneumoniae BSI was seen not only at the patient level, but also at the community level, and was related to multi-drug resistant infection. These findings provide a better understanding of microbial resistance and its association with patient clinical outcomes.

Keywords: Bacteraemia; Klebsiella pneumoniae; Multi-drug resistant; Nosocomial infection; Pan-drug resistant.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Antibiotic susceptibility of Klebsiella pneumoniae bloodstream isolates (n = 152). AMP, ampicillin; AMC, amoxicillin-clavulanate; AMK, amikacin; CEF, cephalothin; COL, colistin; CTZ, ceftazidime; CXM, cefuroxime; CFPM, cefepime; CTX, cefotaxime; CRO, ceftriaxone; CIP, ciprofloxacin; ETP, ertapenem; FOX, cefoxitin; GM, gentamicin; IPM, imipenem; LVX, levofloxacin; MER, meropenem; TGC, tigecycline; TMP-SMX, trimethoprim-sulfamethoxazole; TZP, piperacillin-tazobactam
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