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Review
. 2023 Aug 21:14:1237723.
doi: 10.3389/fphar.2023.1237723. eCollection 2023.

The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Jéssica Manoelli Costa Silva  1 , Eliel Barbosa Teixeira  1 , Ronald Matheus da Silva Mourão  1 , Rafaella Sousa Ferraz  2 , Fabiano Cordeiro Moreira  1 , Paulo Pimentel de Assumpção  1 , Danielle Queiroz Calcagno  1
Affiliations
Review

The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications

Jéssica Manoelli Costa Silva et al. Front Pharmacol. .

Abstract

Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.

Keywords: biomarkers; gastric cancer; gastric carcinogenesis; historical overview; long non-coding RNAs; molecular mechanisms.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Timeline highlighting the key milestones in lncRNA research related to GC.
See this image and copyright information in PMC

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