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. 2023 Jun;7(2):10.31038/edmj.2023724.
doi: 10.31038/edmj.2023724. Epub 2023 Jul 4.

Reversal of Early Increased Anxiety-Like Behavior in the Zucker Fatty versus Lean Rat: Possible Role of Acquired Hormonal Factors

Mihal Grinberg  1 , Mark B Zimering  1   2
Affiliations

Reversal of Early Increased Anxiety-Like Behavior in the Zucker Fatty versus Lean Rat: Possible Role of Acquired Hormonal Factors

Mihal Grinberg et al. Endocrinol Diabetes Metab J. 2023 Jun.
No abstract available

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Figures

Figure 1:
Figure 1:
Center time (sec) in bright light in A) lean or B) fatty Zucker rats after sham- vs. mild TBI. A) Lean: Sham (N=7), TBI (N=6). B) Fatty: Sham (N=5), TBI (N=4).
Figure 2:
Figure 2:
Open field test under dark conditions, 1 month post-injury in Zucker lean and fatty rats. Results are mean ± SEM. Lean: Sham (N=7), TBI (N=6). Fatty: Sham (N=5), TBI (N=4).
Figure 3:
Figure 3:
Center time: significant (strain x time) interaction. Each point is mean ± SEM.
Figure 4:
Figure 4:
Developmental ‘onset’ of reduced anxiety-like behavior in fatty vs. lean Zucker rats. Data are mean ± SEM.
Figure 5:
Figure 5:
Change in body weight in Zucker lean and fatty rats across development and injury (arrowhead). Arrows signify pre-injury, 1-week post and 1-month post-injury timepoints. Each point is mean ± SEM.
Figure 6:
Figure 6:
One week after injury: A) Mean speed and B) distance traveled were both significantly higher in fatty vs. lean Zucker rats; C) total time immobile was significantly higher in lean vs. fatty Zucker rats.
Figure 7:
Figure 7:
A) Zucker fatty (vs. lean) rats traveled significantly greater distance before and 1-week after injury B) Zucker lean (vs. fatty) rats had significantly greater immobility at all three timepoints before and after injury. * P < 0.05
Figure 8:
Figure 8:
SN..8 (vs. scrambled peptide) treatment did not significantly modify time in center in lean or fatty rats evaluated a A) 1 week after sham injury or B) 1 week after mild TBI. Data are mean ± SEM
Figure 9:
Figure 9:
SN..8 (vs. scrambled peptide) treatment did not significantly modify time in center in lean or fatty rats evaluated a A) 1 month after sham injury or B) 1 month after mild TBI. Data are mean ± SEM
See this image and copyright information in PMC

References

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