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Editorial
. 2023 Sep 6;13(9):1966-1968.
doi: 10.1158/2159-8290.CD-23-0727.

So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity

Elise Alspach  1
Affiliations
Editorial

So Grateful for My X: Sex Chromosomes Drive Differences in Glioblastoma Immunity

Elise Alspach. Cancer Discov. .

Abstract

Males are at a greater risk of developing glioblastoma and face poorer prognoses compared with their female counterparts for reasons that are not well understood. Lee and colleagues uncover a role for sex-based differences in CD8+ T-cell function, which adds another layer to our growing understanding that antitumor immunity is not generated equivalently between males and females. See related article by Lee et al., p. 2090 (5).

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  • Sex-Biased T-cell Exhaustion Drives Differential Immune Responses in Glioblastoma.
    Lee J, Nicosia M, Hong ES, Silver DJ, Li C, Bayik D, Watson DC, Lauko A, Kay KE, Wang SZ, Johnson S, McGraw M, Grabowski MM, Kish DD, Desai AB, Goodman WA, Cameron SJ, Okada H, Valujskikh A, Fairchild RL, Ahluwalia MS, Lathia JD. Lee J, et al. Cancer Discov. 2023 Sep 6;13(9):2090-2105. doi: 10.1158/2159-8290.CD-22-0869. Cancer Discov. 2023. PMID: 37378557 Free PMC article.

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