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Comment
. 2023 Sep 5;35(9):1493-1495.
doi: 10.1016/j.cmet.2023.08.007.

Fight, flight, and freeze!

Riya Keshri  1 , Julie Mathieu  2 , Hannele Ruohola-Baker  3
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Fight, flight, and freeze!

Riya Keshri et al. Cell Metab. .
Free article

Abstract

Just like time and tide, embryonic development waits for no man but progresses forcefully to its completion, with just one exception. Diapause is an enigmatic, reversible, dormant halt that protects the developing embryo. Cancer cells have evolved to hijack many useful stem cell capabilities, and diapause is no exception. Recent work has revealed a diapause-like cancer cell state, prompting the quest for its key molecular regulators useful for cancer therapies. The present paper by Sun et al.1 addresses this knowledge gap by revealing a key player in regulating the diapause-like cancer cell stage, the condensin protein SMC4.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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