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. 1986 Aug;30(2):323-4.
doi: 10.1128/AAC.30.2.323.

Activity of roxithromycin (RU 28965), a macrolide, against Toxoplasma gondii infection in mice

J Chan, B J Luft

Activity of roxithromycin (RU 28965), a macrolide, against Toxoplasma gondii infection in mice

J Chan et al. Antimicrob Agents Chemother. 1986 Aug.

Abstract

Roxithromycin (RU 28965), an ether oxime derivative of erythromycin, protected mice against a lethal infection with the virulent RH strain of Toxoplasma gondii. Therapy begun 24 h before, 2 h after, and 24 h after infection with 2 X 10(3) tachyzoites protected 90, 80, and 50% of the mice, compared with 0% of untreated controls (P less than 0.05 to 0.001). Toxoplasma was isolated in less than 20% of surviving roxithromycin-treated mice.

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References

    1. Antimicrob Agents Chemother. 1976 Feb;9(2):222-3 - PubMed
    1. Antimicrob Agents Chemother. 1983 Aug;24(2):209-15 - PubMed
    1. J Immunol. 1984 May;132(5):2375-80 - PubMed
    1. Arch Ophthalmol. 1960 Jul;64:140-6 - PubMed
    1. J Allergy. 1954 Mar;25(2):135-50 - PubMed

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