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. 2023 Nov;261(11):3207-3213.
doi: 10.1007/s00417-023-06227-6. Epub 2023 Sep 6.

Visual field after anti-vascular endothelial growth factor therapy and laser treatment for retinopathy of prematurity

Shumpei Obata  1 , Riko Matsumoto  2 , Maki Iwasa  2 , Masashi Kakinoki  2 , Osamu Sawada  2 , Tomoko Sawada  2 , Yoshitsugu Saishin  2 , Masahito Ohji  2
Affiliations

Visual field after anti-vascular endothelial growth factor therapy and laser treatment for retinopathy of prematurity

Shumpei Obata et al. Graefes Arch Clin Exp Ophthalmol. 2023 Nov.

Abstract

Purpose: To evaluate the visual field after anti-vascular endothelial growth factor (VEGF) therapy and laser treatment for retinopathy of prematurity.

Method: Retrospective cohort study. Infants with retinopathy of prematurity treated by anti-VEGF therapy or laser treatment were included in the study. Degrees of visual field in eight directions examined by Goldmann perimeter (intensity, 1000 apostilb; size, V4e = 64 mm2) were compared between the anti-VEGF therapy and laser treatment groups. The visual acuity (VA) and spherical equivalent refraction were also compared between the two groups.

Results: Nine eyes with anti-VEGF therapy and 12 eyes with laser treatment were enrolled in the analysis. The total, upper, nasal upper, nasal, nasal lower, temporal lower, and temporal upper visual fields were significantly wider in the eyes with anti-VEGF therapy than in those with laser treatment (496 vs 416, P = .002; 53 vs 45, P = .008; 56 vs 43, P = .003; 58 vs 39, P < .001; 55 vs 44, P = .01; 72 vs 65, P = .01; and 62 vs 56, P = .03, respectively). The logarithm of the minimum angle of resolution VA tended to be better in the eyes with anti-VEGF therapy than in those with laser treatment (0.01 vs 0.15, P = .06). Eyes with anti-VEGF therapy had significantly lower myopia than those with laser treatment (spherical equivalent refraction: -0.72 vs -5.7, P = .001).

Conclusion: Anti-VEGF therapy may provide a wider visual field, better VA, and less myopia compared with laser treatment.

Keywords: Laser; Retinopathy of prematurity; Treatment; Vascular endothelial growth factor; Visual field.

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References

    1. Gilbert C (2008) Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control. Early Hum Dev 84:77–82. https://doi.org/10.1016/j.earlhumdev.2007.11.009 - DOI - PubMed
    1. Quinn GE, Dobson V, Davitt BV, Hardy RJ, Tung B, Pedroza C, Good WV, Early Treatment for Retinopathy of Prematurity Cooperative G (2008) Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age. Ophthalmology 115:1058-1064 e1051. https://doi.org/10.1016/j.ophtha.2007.07.028 - DOI - PubMed
    1. Quinn GE, Dobson V, Davitt BV, Wallace DK, Hardy RJ, Tung B, Lai D, Good WV, Early Treatment for Retinopathy of Prematurity Cooperative G (2013) Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings at 4 to 6 years of age. J AAPOS 17:124–128. https://doi.org/10.1016/j.jaapos.2012.10.025 - DOI - PubMed - PMC
    1. McLoone E, O’Keefe M, McLoone S, Lanigan B (2007) Effect of diode laser retinal ablative therapy for threshold retinopathy of prematurity on the visual field: results of Goldmann perimetry at a mean age of 11 years. J Pediatr Ophthalmol Strabismus 44:170–173. https://doi.org/10.3928/0191-3913-20070301-10 - DOI - PubMed
    1. Early Treatment For Retinopathy Of Prematurity Cooperative G (2003) Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol 121:1684–1694. https://doi.org/10.1001/archopht.121.12.1684 - DOI

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