Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug 9;9(9):e18917.
doi: 10.1016/j.heliyon.2023.e18917. eCollection 2023 Sep.

Nanofibers: A current era in drug delivery system

Abhijeet Hiwrale  1 , Swati Bharati  1 , Prashant Pingale  2 , Amarjitsing Rajput  1
Affiliations
Review

Nanofibers: A current era in drug delivery system

Abhijeet Hiwrale et al. Heliyon. .

Abstract

Nanofibers have a large area of surface variable 3D topography, porosity, and adaptable surface functions. Several researchers are researching nanofiber technology as a potential solution to the current problems in several fields. It manages cardiovascular disorders, infectious diseases, gastrointestinal tract-associated diseases, neurodegenerative diseases, pain treatment, contraception, and wound healing. The nanofibers are fabricated using various fabrication techniques, such as electrospinning, phase separation, physical Fabrication, and chemical fabrication. Depending on their intended use, nanofibers are manufactured using a variety of polymers. It comprises natural polymers, semi-synthetic polymers, synthetic polymers, metals, metal oxides, ceramics, carbon, nonporous materials, mesoporous materials, hollow structures, core-shell structures, biocomponents, and multi-component materials. Nanofiber composites are a good alternative for targeted gene delivery, protein and peptide delivery, and growth factor delivery. Thus, nanofibers have huge potential in drug delivery, which enables them to be used for various applications and can revolutionize these therapeutic areas. This review systematically studied nanofibers' history, advantages, disadvantages, types, and polymers used in nanofiber technology. Further, polymers and their types used in the preparation of nanofibers were summarised. Mainly review article focuses on the fabrication method, i.e., electrospinning and its types. Finally, the article discussed the applications and recent advancements of nanofabrication technology.

Keywords: Electrospinning; Gene delivery; Nanofiber; Polymers; Tissue engineering.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Manufacturing and handling of nanomaterials.
Fig. 2
Fig. 2
Representation of the electrospinning method.
Fig. 3
Fig. 3
Polymers used in nanofiber technology.
Fig. 4
Fig. 4
Different types of nozzles used in electrospinning.
Fig. 5
Fig. 5
Applications of nanofiber in various diseases.
See this image and copyright information in PMC

References

    1. Barhoum A., et al. Vol. 17. 2019. pp. 1–35. (Nanofibers as new-generation materials: From spinning and nano-spinning fabrication techniques to emerging applications).
    1. Harish V., et al. 2022. Review On Nanoparticles And Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, And Agro-Food Applications; p. 457. 12(3) - PMC - PubMed
    1. Fathi-Achachelouei M., et al. Vol. 7. 2019. p. 113. (Use of nanoparticles in tissue engineering and regenerative medicine). - PMC - PubMed
    1. Omer S., et al. 2021. Scale-Up Of Electrospinning: Market Overview Of Products And Devices For Pharmaceutical And Biomedical Purposes; p. 286. 13(2) - PMC - PubMed
    1. Wang X.-X., et al. Conductive polymer ultrafine fibers via electrospinning: preparation, physical properties and applications. Prog. Mater. Sci. 2021;115

LinkOut - more resources