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Comment
. 2023 Sep 6;111(17):2615-2617.
doi: 10.1016/j.neuron.2023.08.011.

NaV1.7: A central role in pain

Stephen G Waxman  1 , Sulayman D Dib-Hajj  2
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Comment

NaV1.7: A central role in pain

Stephen G Waxman et al. Neuron. .
Free article

Abstract

Loss of function of sodium channel NaV1.7 produces pain insensitivity. In this issue, Deng et al.1 show that analgesia after NaV1.7 removal or pharmacological blockade is not driven by enkephalin overexpression. These results underscore the essential role, independent of endogenous opioids, of NaV1.7 for nociceptor firing and pain.

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Conflict of interest statement

Declaration of interests S.G.W. has served as a paid advisor to Olipass Therapeutics, Sangamo Pharma, Exicure Research, Envida Biopharma, Chromocell, Third Rock Bioventures, MedTronic, and Alnylam. He holds stocks in Navega Therapeutics and Site One Therapeutics. S.D.H. received consulting fees from Alnaylum and holds stocks in Pfizer Pharmaceuticals.

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