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. 2023 Dec 1;24(12):e602-e610.
doi: 10.1097/PCC.0000000000003374. Epub 2023 Sep 7.

Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study

Julie Levasseur  1 , Lauren Fikse  2 , Audrey Mauguen  3 , James S Killinger  2   4 , Oliver Karam  5 , Marianne E Nellis  2   4
Affiliations

Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study

Julie Levasseur et al. Pediatr Crit Care Med. .

Abstract

Objectives: To determine the incidence of bleeding in critically ill children with malignancy and to describe associated patient characteristics, interventions, and clinical outcomes.

Design: Prospective cohort study.

Setting: PICU in a specialized cancer hospital.

Patients: Children with malignancy or hematopoietic cell transplant 0-18 years of age were admitted to the PICU from November 2020 to November 2021.

Interventions: None.

Measurements: Patient demographic data, laboratory values, and PICU outcome data were collected. Bleeding was classified according to the Bleeding Assessment Scale in Critically Ill Children.

Main results: Ninety-three bleeding patients were enrolled, and a total of 322 bleeding days were recorded. The median (interquartile range [IQR]) age was 5.8 (2.9-11.8) years and 56% (52/93) of the patients were male. There were 121 new bleeding episodes, in 593 at-risk person-days, translating into a 20% incidence rate per day (95% CI, 17-24%). The incidence of severe, moderate, and minimal bleeding was 2% (95% CI, 1-3), 4% (95% CI, 3-6), and 14% (95% CI, 12-17), respectively. Of the new bleeding episodes, 9% were severe, 25% were moderate and 66% were minimal. Thrombocytopenia was the only laboratory value independently associated with severe bleeding ( p = 0.009), as compared to minimal and moderate bleeding episodes. History of radiation therapy was independently associated with severe bleeding ( p = 0.04). We failed to identify an association between a history of stem cell transplant ( p = 0.49) or tumor type ( p = 0.76), and bleeding severity. Patients were transfused any blood product on 28% (95% CI, 22-34) of the bleeding days. Severe bleeding was associated with increased length of mechanical ventilation ( p = 0.003), longer PICU stays ( p = 0.03), and higher PICU mortality ( p = 0.004).

Conclusions: In this prospective cohort of children with malignancy, the incidence rate of bleeding was 20%. Most events were classified as minimal bleeding. Low platelet count and radiation therapy were variables independently associated with severe bleeding episodes.

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Conflict of interest statement

The study was supported by the MSK Cancer Center Support Grant/Core Grant (P30 CA008748). Drs. Nellis and Mauguen received support for article research from the National Institutes of Health (NIH). Dr. Mauguen’s institution received funding from the NIH (P30 CA008748). The remaining authors have disclosed that they do not have any potential conflicts of interest.

Figures

Figure 1:
Figure 1:
Transfusion of Blood Products by Bleeding Severity (all bleeding days, n=322 days)
See this image and copyright information in PMC

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