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Review
. 2023 Oct 15:957:176039.
doi: 10.1016/j.ejphar.2023.176039. Epub 2023 Sep 5.

The role of BRG1 in epigenetic regulation of cardiovascular diseases

Zi-Yue Ma  1 , Jing Li  1 , Xian-Hui Dong  1 , Ying-Tao Cui  1 , Yun-Feng Cui  1 , Tao Ban  2 , Rong Huo  3
Affiliations
Review

The role of BRG1 in epigenetic regulation of cardiovascular diseases

Zi-Yue Ma et al. Eur J Pharmacol. .

Abstract

Cardiovascular diseases have been closely linked to abnormal epigenetic regulation. In the context of epigenetic regulation, BRG1, a pivotal SWI/SNF chromatin remodeling enzyme, emerges as a key epigenetic regulator with significant impact on the development and progression of cardiovascular disorders. From the perspective of epigenetic regulation of cardiovascular diseases, BRG1 emerges as a pivotal SWI/SNF chromatin remodeling enzyme, functioning as a key epigenetic regulator. It exerts substantial influence on the development and progression of cardiovascular disorders by exerting precise control over gene expression and protein levels. Therefore, a comprehensive understanding of BRG1's epigenetic regulatory role in cardiovascular disease is essential for unraveling its underlying pathophysiological mechanisms. This paper summarizes and discusses the function of BRG1 in the epigenetic regulation of cardiovascular diseases.

Keywords: BRG1; Cardiovascular disease; Epigenetic regulator.

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Conflict of interest statement

Declaration of competing interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.

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