Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

doi:10.1038/s41575-023-00832-w

Review

. 2023 Oct;20(10):662-678.

doi: 10.1038/s41575-023-00832-w. Epub 2023 Sep 7.

Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

Sachin Sharma^#^{1

2}, Dounia Le Guillou^#^{1

2}, Jennifer Y Chen^{3

4}

Affiliations

¹ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
² The Liver Center, University of California, San Francisco, San Francisco, CA, USA.
³ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Jennifer.Chen4@ucsf.edu.
⁴ The Liver Center, University of California, San Francisco, San Francisco, CA, USA. Jennifer.Chen4@ucsf.edu.

^# Contributed equally.

PMID: 37679454
DOI: 10.1038/s41575-023-00832-w

Review

Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

Sachin Sharma et al. Nat Rev Gastroenterol Hepatol. 2023 Oct.

. 2023 Oct;20(10):662-678.

doi: 10.1038/s41575-023-00832-w. Epub 2023 Sep 7.

Authors

Sachin Sharma^#^{1

2}, Dounia Le Guillou^#^{1

2}, Jennifer Y Chen^{3

4}

Affiliations

¹ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
² The Liver Center, University of California, San Francisco, San Francisco, CA, USA.
³ Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. Jennifer.Chen4@ucsf.edu.
⁴ The Liver Center, University of California, San Francisco, San Francisco, CA, USA. Jennifer.Chen4@ucsf.edu.

^# Contributed equally.

PMID: 37679454
DOI: 10.1038/s41575-023-00832-w

Abstract

The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized by excessive deposition of extracellular matrix proteins, is the common pathway leading to cirrhosis, and limited treatment options are available. There is increasing evidence suggesting the role of cellular stress responses contributing to fibrogenesis. This Review provides an overview of studies that analyse the role of cellular stress in different cell types involved in fibrogenesis, including hepatocytes, hepatic stellate cells, liver sinusoidal endothelial cells and macrophages.

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References

1. Cheemerla, S. & Balakrishnan, M. Global epidemiology of chronic liver disease. Clin. Liver Dis. 17, 365–370 (2021). - DOI
1. Rinella, M. E. et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Hepatology https://doi.org/10.1097/HEP.0000000000000520 (2023). - DOI - PubMed
1. Kisseleva, T. & Brenner, D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat. Rev. Gastroenterol. Hepatol. 18, 151–166 (2021). - PubMed - DOI
1. Lu, M. et al. Serum biomarkers indicate long-term reduction in liver fibrosis in patients with sustained virological response to treatment for HCV infection. Clin. Gastroenterol. Hepatol. 14, 1044–1055.e3 (2016). - PubMed - PMC - DOI
1. Iwaisako, K. et al. Origin of myofibroblasts in the fibrotic liver in mice. Proc. Natl Acad. Sci. USA 111, E3297–E3305 (2014). - PubMed - PMC - DOI

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[1] Cheemerla, S. & Balakrishnan, M. Global epidemiology of chronic liver disease. Clin. Liver Dis. 17, 365–370 (2021). - DOI

[2] Cheemerla, S. & Balakrishnan, M. Global epidemiology of chronic liver disease. Clin. Liver Dis. 17, 365–370 (2021). - DOI

[3] Rinella, M. E. et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Hepatology https://doi.org/10.1097/HEP.0000000000000520 (2023). - DOI - PubMed

[4] Rinella, M. E. et al. A multi-society Delphi consensus statement on new fatty liver disease nomenclature. Hepatology https://doi.org/10.1097/HEP.0000000000000520 (2023). - DOI - PubMed

[5] Kisseleva, T. & Brenner, D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat. Rev. Gastroenterol. Hepatol. 18, 151–166 (2021). - PubMed - DOI

[6] Kisseleva, T. & Brenner, D. Molecular and cellular mechanisms of liver fibrosis and its regression. Nat. Rev. Gastroenterol. Hepatol. 18, 151–166 (2021). - PubMed - DOI

[7] Lu, M. et al. Serum biomarkers indicate long-term reduction in liver fibrosis in patients with sustained virological response to treatment for HCV infection. Clin. Gastroenterol. Hepatol. 14, 1044–1055.e3 (2016). - PubMed - PMC - DOI

[8] Lu, M. et al. Serum biomarkers indicate long-term reduction in liver fibrosis in patients with sustained virological response to treatment for HCV infection. Clin. Gastroenterol. Hepatol. 14, 1044–1055.e3 (2016). - PubMed - PMC - DOI

[9] Iwaisako, K. et al. Origin of myofibroblasts in the fibrotic liver in mice. Proc. Natl Acad. Sci. USA 111, E3297–E3305 (2014). - PubMed - PMC - DOI

[10] Iwaisako, K. et al. Origin of myofibroblasts in the fibrotic liver in mice. Proc. Natl Acad. Sci. USA 111, E3297–E3305 (2014). - PubMed - PMC - DOI

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Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

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Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis

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