Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;36(8):838-841.
doi: 10.1038/s41443-023-00760-y. Epub 2023 Sep 8.

Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX analysis

Affiliations

Oxycodone prescription after inflatable penile prosthesis has risks of persistent use: a TriNetX analysis

Zachary J Prebay et al. Int J Impot Res. 2024 Dec.

Abstract

We sought to evaluate the impact of Oxycodone prescriptions on short-term patient outcomes and long-term Oxycodone use following inflatable penile prosthesis (IPP) placement. We queried the TriNetX research database for all adult patients undergoing IPP. Cohorts included opioid naïve patients prescribed postoperative Oxycodone against propensity score-matched patients without a prescription. We compared return visits to the emergency department (ED) within 14 and 90 days of surgery, a diagnosis of opioid abuse or dependence disorder 6 months or later after surgery and persistent Oxycodone use 9-15 months after surgery. After matching, there were 2433 patients in each group. There was an increase in 90-day ED visits based on receipt of Oxycodone (6.8% of patients vs 5.0%, risk ratio (RR) 1.4 95% confidence interval (CI) [1.1, 1.7]). Groups had similar 14-day ED visits (3.7% of patients vs 2.9%, RR 1.3, 95% CI [0.95, 1.7]). Patients prescribed Oxycodone (5.1% of patients vs 2.7%, RR 1.9, 95% CI [1.4, 2.6]) were more likely to have persistent Oxycodone use at 9-15 months. There were low instances of diagnosis of opioid dependence or abuse for both groups limiting comparison. Oxycodone prescription after IPP has risks of persistent use and withholding Oxycodone does not appear to increase postoperative healthcare utilization.

PubMed Disclaimer

Conflict of interest statement

Competing interests: PHC consults for and receives research support from Boston Scientific and Coloplast. The remaining authors declare no competing interests. Ethics approval: This study population was an entirely deidentified analysis from a third-party research database. Thus, this study was considered exempt from institutional review board approval.

References

    1. Theisen K, Jacobs B, Macleod L, Davies B. The United States opioid epidemic: a review of the surgeon’s contribution to it and health policy initiatives. BJU Int. 2018;122:754–9. - DOI - PubMed
    1. Carnes KM, Singh Z, Ata A, Mian BM. Interventions to reduce opioid prescriptions following urological surgery: a systematic review and meta-analysis. J Urol. 2022;207:969–81. - DOI - PubMed
    1. Anderson DJ, Cao DY, Zhou J, McDonald M, Razzak AN, Hasoon J, et al. Opioids in urology: how well are we preventing opioid dependence and how can we do better? Health Psychol Res. 2022;10:38243. - DOI - PubMed - PMC
    1. Amend GM, Hakam N, Nabavizadeh B, Sadighian MJ, Holler JT, Rios N, et al. Institutional opioid prescription guidelines are effective in reducing post-operative prescriptions following urologic surgery: results from the American Urologic Association 2018 Census. Urology. 2021;158:5–10. - DOI - PubMed
    1. Jacobs BL, Rogers D, Yabes JG, Bandari J, Ayyash OM, Maganty A, et al. Large reduction in opioid prescribing by a multipronged behavioral intervention after major urologic surgery. Cancer. 2021;127:257–65. - DOI - PubMed

LinkOut - more resources