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. 2023 Oct;43(5):1026-1033.
doi: 10.19852/j.cnki.jtcm.2023.05.006.

Xiaoyi Yusi decoction improves fertilization and embryo transfer outcomes in patients with endometriosis

Jiang Wenjing  1 , Jiang Huaying  2   3 , Yuan Lihua  4 , S A Yuanhong  5 , Xiao Jimei  6 , Sun Hongqi  7 , Song Jingyan  4   8 , Sun Zhengao  4   8
Affiliations

Xiaoyi Yusi decoction improves fertilization and embryo transfer outcomes in patients with endometriosis

Jiang Wenjing et al. J Tradit Chin Med. 2023 Oct.

Abstract

Objective: To investigate the effect of - Xiaoyi Yusi decoction (XYYSD, ), a Traditional Chinese Medicine (TCM), on fertilization and embryo transfer (IVF-ET) in patients with endometriosis, and to study the mechanism underpinning the action.

Methods: Women who underwent IVF-ET were divided into three groups by simple randomization: the treatment ( 32; with TCM treatment), patient (28; with endometriosis alone), and control (33; with male factor alone) groups. The luteal phase short-acting gonadotropin-releasing hormone agonist prolonged protocol was used in all three groups. To compare the changes in TCM scores and reproductive outcomes before and after TCM intervention in patients with endometriosis, partial least-squares discriminant analysis was used to analyze the follicular fluid samples of each group and screen and compare metabolites using the MetaboAnalyst software.

Results: The clinical data indicated that following TCM intervention, kidney deficiency and blood stasis symptom patterns improved dramatically in patients with endometriosis and that their clinical pregnancy rate increased significantly (71.9% 57.1%, 0.05). Metabolomics showed that the two groups of samples were separated before and after TCM intervention. After TCM intervention, the intervention group was close to the control group, indicating that the TCM had a certain effect. Pathway analysis revealed that after TCM intervention, the metabolism of glycerin phospholipid, pyruvate, and citric acid was regulated.

Conclusions: Through the pyruvate and glycerophospholipid metabolism pathways and tricarboxylic acid cycle, the TCM XYYSD successfully improved kidney deficiency and blood stasis symptom pattern, as well as the clinical reproductive outcomes of patients with endometriosis-related infertility.

Keywords: Xiaoyi Yusi decoction; blood stasis; embryo transfer; endometriosis; fertilization; infertility; kidney deficiency; metabolomics.

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Figures

Figure 1
Figure 1. Partial least-squares discriminant analysis scores plot in follicular fluid metabolomics analysis
Figure 2
Figure 2. Heat map from the data of significantly differential metabolites
The horizontal axis of the figure shows a dendrogram of the samples. The vertical axis of the figure shows a dendrogram of the metabolite differences.
Figure 3
Figure 3. VIP scores of each potential biomarker to the discrimination between the patient group and the treatment group
The contribution of every potential biomarker to the discrimination between the patient group and the treatment group were ranked as VIP scores. VIP: variable importance in projection.
Figure 4
Figure 4. Metabolic pathway analysis of significantly changed metabolites between the patient group and the treatment group
The results showed that pyruvate and glycerophospholipid metabolism pathways and the citrate cycle are closely related to endometriosis, indicating that they may be targetted in the treatment of endometriosis with XYYSD. XYYSD: Xiaoyi Yusi decoction.
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