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. 2023 Aug 11;35(1):36-41.
doi: 10.4103/joco.joco_189_22. eCollection 2023 Jan-Mar.

Evaluation of Choroidal Vascularity Index in Keratoconus Patients: Does Choroidal Vascularity Change in Keratoconus?

Mohammad Naser Hashemian  1 , Sadegh Ghafarian  1 , Hamid Riazi-Esfahani  1 , Elias Khalili Pour  1
Affiliations

Evaluation of Choroidal Vascularity Index in Keratoconus Patients: Does Choroidal Vascularity Change in Keratoconus?

Mohammad Naser Hashemian et al. J Curr Ophthalmol. .

Abstract

Purpose: To investigate the choroidal structure in keratoconic patients with different severity using the choroidal vascularity index (CVI) derived from image binarization on enhanced depth imaging optical coherence tomography scans (EDI-OCT).

Methods: Sixty-eight eyes from 34 keratoconus (KCN) patients and 72 eyes from 36 healthy subjects were recruited in this prospective, noninterventional, comparative cross-sectional study. EDI-OCT was employed to measure choroidal parameters, including choroidal thickness (CT), total choroidal area (TCA), luminal area, stromal area, and CVI.

Results: Subfoveal CT was 354.6 ± 66.8 μm in the control group and 371 ± 64.5 μm in the KCN group (P = 0.86). There was no significant difference between control and KCN groups in terms of TCA (0.66 ± 0.14 mm2 vs. 0.7 ± 0.12 mm2; P = 0.70), luminal area (0.49 ± 0.10 mm2 vs. 0.53 ± 0.08 mm2; P = 0.67), and stromal area (0.16 ± 0.05 mm2 vs. 0.17 ± 0.05 mm2; P = 0.84). CVI was also comparable in the control group (75.4% ±3.4%) and the KCN group (75.6% ±4.5%; P = 0.43). There was also no significant correlation between other choroidal parameters and KCN severity indices.

Conclusion: It seems that CVI as well as other choroidal biomarkers were not significantly different between patients with KCN and healthy subjects.

Keywords: Choroidal thickness; Choroidal vascularity index; Enhanced depth imaging optical coherence tomography scans; Keratoconus.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Enhanced depth imaging optical coherence tomography scan of the foveal area. Representation of a choroidal thickness measurement from the outer edge of the hyperreflective line (red asterisk), corresponding to the retinal pigment epithelium and Bruch’s membrane, to the choroidal-scleral junction (yellow dotted line). Measurements were taken at the subfoveal choroid with ruler tool
Figure 2
Figure 2
Representation of binarization technique for choroidal vascular index measurement. The image was converted to 8-bit and Niblack auto local threshold tool was applied. The luminal area (white arrow) and the stromal area (red arrow) are shown in black and white colors, respectively, after the binarization process
See this image and copyright information in PMC

References

    1. Espandar L, Meyer J. Keratoconus: Overview and update on treatment. Middle East Afr J Ophthalmol. 2010;17:15–20. - PMC - PubMed
    1. Mas Tur V, MacGregor C, Jayaswal R, O'Brart D, Maycock N. A review of keratoconus: Diagnosis, pathophysiology, and genetics. Surv Ophthalmol. 2017;62:770–83. - PubMed
    1. Volatier TL, Figueiredo FC, Connon CJ. Keratoconus at a molecular level: A review. Anat Rec (Hoboken) 2020;303:1680–8. - PubMed
    1. Galvis V, Sherwin T, Tello A, Merayo J, Barrera R, Acera A. Keratoconus: An inflammatory disorder? Eye (Lond) 2015;29:843–59. - PMC - PubMed
    1. Ferrari G, Rama P. The keratoconus enigma: A review with emphasis on pathogenesis. Ocul Surf. 2020;18:363–73. - PubMed