Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 1:16:903-913.
doi: 10.2147/JAA.S402674. eCollection 2023.

Pre-Existing Allergies Patients with Higher Viral Load and Longer Recovery Days Infected by SARS-CoV-2 Omicron BA.2 in Shanghai, China, 2022

Ru Wen #  1   2   3 , Jingwen Li #  4 , Xingang Wang #  1 , Peng Xu  1 , Guizhu Li  5 , Jian Wang  1 , Xianchun Zeng  2   6 , Chen Liu  1
Affiliations

Pre-Existing Allergies Patients with Higher Viral Load and Longer Recovery Days Infected by SARS-CoV-2 Omicron BA.2 in Shanghai, China, 2022

Ru Wen et al. J Asthma Allergy. .

Abstract

Background: It is not known whether the viral load and the number of days to negative nucleic acid increased in patients with a history of allergy during the COVID-19 pandemic.

Objective: To investigate the impact of allergy labels on SARS-CoV-2 Omicron outcomes.

Methods: This retrospective cohort study included 62,293 patients with mild Omicron infection between April 9, 2022, and May 31, 2022. Using 1:2 propensity score matching, we identified 2177 COVID-19 patients with a history of allergy and 4254 COVID-19 patients with no history of allergy. The differences in viral load, days to nucleic acid turning negative, and clinical symptoms were compared between the two groups.

Results: Compared with the group with no allergies, the number of days before negative nucleic acid conversion of COVID-19 patients with allergies was significantly higher, the viral load was significantly higher, and the cumulative negative conversion rates at 5-10 days were all lower (p < 0.01). Patients with a history of allergy to antibiotics had higher viral load and more days with negative nucleic acid levels (p < 0.001). Subgroup analysis revealed that the viral load in penicillin-allergic and cephalosporins-allergic patients was significantly compared to patients without any history of allergies (p < 0.05).

Conclusion: Patients with a history of allergy have a more significant viral load and a longer duration of nucleic acid negative conversion upon COVID-19 infection, particularly those allergic to antibiotics.

Keywords: COVID-19; allergy history; antibiotics allergy; ct value; nucleic acid turning-negative-time; omicron.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Flow chart of the inclusion and exclusion criteria of the study sample.
Figure 2
Figure 2
Overall survival analysis performed in the allergy group and non-allergy groups. The Kaplan–Meier method is used to analyze the time to the primary endpoint using a Log rank test.
Figure 3
Figure 3
Overall survival analysis performed in the antibiotic allergy group and non-allergy group. The Kaplan–Meier method is used to analyze the time to the primary endpoint using a Log rank test.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Available from: https://covid19.who.int/. Accessed July 31, 2023.
    1. Hoffmann M, Kruger N, Schulz S, et al. The Omicron variant is highly resistant against antibody-mediated neutralization: implications for control of the COVID-19 pandemic. Cell. 2022;185:447–56 e11. - PMC - PubMed
    1. Du H, Dong X, Zhang JJ, et al. Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status. Allergy. 2021;76(2):510–532. doi:10.1111/all.14452 - DOI - PMC - PubMed
    1. Baseggio Conrado A, Ierodiakonou D, Gowland MH, Boyle RJ, Turner PJ. Food anaphylaxis in the United Kingdom: analysis of national data, 1998–2018. BMJ. 2021;372:n251. doi:10.1136/bmj.n251 - DOI - PMC - PubMed
    1. Krishnamoorthy N, Douda DN, Bruggemann TR, et al. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018;3(26). doi:10.1126/sciimmunol.aao4747 - DOI - PMC - PubMed