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. 2022 Sep 30;12(3):344-351.
doi: 10.18683/germs.2022.1338. eCollection 2022 Sep.

Risk factors for mortality in hospitalized patients infected with carbapenem-resistant Pseudomonas aeruginosa in Iran

Younes Khalili  1 , Pooya Omidnia  2 , Hamid Reza Goli  3 , Sajjad Zamanlou  4 , Farhad Babaie  5 , Abed Zahedi Bialvaei  6
Affiliations

Risk factors for mortality in hospitalized patients infected with carbapenem-resistant Pseudomonas aeruginosa in Iran

Younes Khalili et al. Germs. .

Abstract

Introduction: Mortality due to carbapenem-resistant Pseudomonas aeruginosa (CRPA) infection has increased worldwide in recent years. The risk factors associated with hospital settings in Iran and the role of strain resistance mechanisms in many studies are unclear.

Methods: A retrospective study was conducted on consecutive non-repetitive patients with CRPA infections isolated from seven major hospitals from northwest of Iran. We evaluated different risk factors and characteristics of bacteria for the death or survival of patients.

Results: In this study, 116 CRPA isolates were obtained from patients admitted to seven hospitals. Forty-one (35.3%) patients were enrolled in the study of mortality risk factors. Significant risk factors associated with mortality included the site of infection, hospitalization in different wards, the use of invasive devices, and the type of carbapenem resistance mechanisms.

Conclusions: ICU admission, the use of mechanical ventilation and chest tube and infection with pandrug-resistant strains were the most important factors in increasing mortality due to CRPA infection. These results suggested that the clinicians should emphasize the proper use of antibiotic and invasive procedures.

Keywords: Carbapenem; Pseudomonas aeruginosa; mortality; risk factor.

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Conflict of interest statement

Conflicts of interest: All authors – none to declare.

Figures

Figure 1
Figure 1
Cross-sectional study design and study flow chart CRPA - carbapenem-resistant P. aeruginosa
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