Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep-Oct;39(5):1440-1445.
doi: 10.12669/pjms.39.5.6405.

Cytogenetic profile of Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia in Northern Pakistan

Maria Khan  1 , Chaudhry Altaf  2 , Hamid Saeed Malik  3 , Mohammad Abdul Naeem  4
Affiliations

Cytogenetic profile of Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia in Northern Pakistan

Maria Khan et al. Pak J Med Sci. 2023 Sep-Oct.

Abstract

Objective: To determine the frequencies of different cytogenetic abnormalities in patients of Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia in Northern Pakistan.

Methods: It was descriptive cross-sectional study conducted in Hematology Department of a Tertiary care referral institute from June 2015 to July 2017. All newly diagnosed cases of Acute Leukemia were analyzed. Cytogenetic analysis was performed on bone marrow aspirate samples using Giemsa-trypsin banding technique. Karyotypes were identified and interpreted according to ISCN criteria.

Results: A total of 355 newly diagnosed patients of Acute Leukemia were analyzed. Out of these, 180 patients had AML and 175 had ALL. In Acute Myeloid Leukemia chromosomal abnormalities were detected in 28.2 % cases. Of these the common ones included t(8;21),t(15;17),+8, Inversion 16 and Monosomy 7. Other abnormalities included Complex karyotype, Down's syndrome related AML, Hyperdiploidy, del 16q,-8,+Y and t(3p;17q)del 10. In Acute Lymphoblastic Leukemia chromosomal abnormalities were detected in 40% cases. Common ones included Hyperdiploidy, Tetraploidy and t(9;22). Other abnormalities included t(1;19) and t(2;8)t(8;14).

Conclusion: Cytogenetically favorable abnormalities are commonest occurring chromosomal defects in both Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia in Northern Pakistan, i.e., t(8;21) in AML and Hyperdiploidy in ALL.

Keywords: Acute lymphoblastic leukemia (ALL); Acute myeloid leukemia (AML); Cytogenetics; Metaphase.

PubMed Disclaimer

Conflict of interest statement

Financial Disclosures and conflict of interest: None.

Figures

Fig.1
Fig.1
Age distribution pattern in Acute Myeloid Leukemia with cytogenetic abnormalities.
Fig.2
Fig.2
Age distribution pattern in Acute Lymphoblastic Leukemia with cytogenetic abnormalities.
See this image and copyright information in PMC

References

    1. Saultz JN, Garzon R. Acute myeloid leukemia:a concise review. J Clin Med. 2016;5(3):33. https://doi.org/10.3390/jcm5030033. - PMC - PubMed
    1. Terwilliger T, Abdul-Hay MJ. Acute lymphoblastic leukemia:a comprehensive review and 2017 update. Blood Cancer J. 2017;7(6):e577. https://doi.org/10.1038/bcj.2017.53. - PMC - PubMed
    1. McKenna R. Multifaceted Approach to the Diagnosis and Classification of Acute Leukemias. Clin Chem. 2000;46(8):1252–1259. https://doi.org/10.1093/clinchem/46.8.1252. - PubMed
    1. Vardiman J, Thiele J, Arber D. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia:rationale and important changes. Blood. 2009;114(5):937–951. https://doi.org/10.1182/blood-2009-03-209262. - PubMed
    1. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391–405. doi: 10.1182/blood-2016-03-643544. - PubMed

LinkOut - more resources