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Review
. 2024 Feb;94(1):79-91.
doi: 10.1111/prd.12521. Epub 2023 Sep 8.

Optimization of platelet-rich fibrin

Richard J Miron  1 , Masako Fujioka-Kobayashi  2 , Anton Sculean  1 , Yufeng Zhang  3
Affiliations
Free article
Review

Optimization of platelet-rich fibrin

Richard J Miron et al. Periodontol 2000. 2024 Feb.
Free article

Abstract

The use of platelet-rich fibrin (PRF) has gained tremendous popularity in recent years owing to its ability to speed wound healing postsurgery. However, to date, many clinicians are unaware of methods designed to optimize the technology. This overview article will discuss the advancements and improvements made over the years aimed at maximizing cell and growth factor concentrations. First, a general understanding explaining the differences between RPM and RCF (g-force) is introduced. Then, the low-speed centrifugation concept, fixed angle versus horizontal centrifugation, and methods to maximize platelet concentrations using optimized protocols will be discussed in detail. Thereafter, the importance of chemically modified PRF tubes without the addition of chemical additives, as well as regulation of temperature to induce/delay clotting, will be thoroughly described. This article is a first of its kind summarizing all recent literature on PRF designed to optimize PRF production for clinical treatment.

Keywords: L‐PRF; horizontal centrifugation; platelet‐rich fibrin; tissue regeneration; wound healing.

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References

REFERENCES

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