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Meta-Analysis
. 2023 Sep 8;102(36):e34922.
doi: 10.1097/MD.0000000000034922.

Meta-analysis of the effect of laparoscopic surgery and open surgery on long-term quality of life in patients with colorectal cancer

Mengfan Cui  1 , Shimin Liu
Affiliations
Meta-Analysis

Meta-analysis of the effect of laparoscopic surgery and open surgery on long-term quality of life in patients with colorectal cancer

Mengfan Cui et al. Medicine (Baltimore). .

Abstract

Objective: To compare the effect of laparoscopic surgery and open surgery on the quality of life of patients with colorectal cancer (CRC) in the growth period after the operation, and to provide a reference for surgical treatment decisions of patients with CRC.

Methods: PubMed/MEDLINE, EMBASE, Web of Science, and Cochrane databases were searched through May 7, 2022 for clinical studies comparing the postoperative quality of life in CRC patients who underwent laparoscopic surgery with those who underwent open surgery. Data were extracted from eligible studies following rigorous quality review. All studies included patient numbers, surgery type, follow-up length, and quality of life scores.

Results: A total of 6 studies were included, resulting in significantly better physical functioning scores with laparoscopic versus open surgery. (Standardized mean difference = 0.45; 95% CI (0.15, 0.75), P = .003). However, in general health, social functioning, bodily pain, vitality, quality of life index, Global Quality Scale, physical component summary and mental component summary, there was no telling difference between the 2 surgical therapies.

Conclusion: Compared with open surgery, laparoscopic surgery has weak advantages. There was no noteworthy difference in the long-term quality of life between the 2 surgical treatments for CRC patients. Whether laparoscopic surgery can bring more improvement to the quality of life of patients with CRC needs more high-quality clinical randomized studies to verify.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Flow diagram for study selection process.
Figure 2.
Figure 2.
Assessment of risk of bias in included studies.
Figure 3.
Figure 3.
Forest plot of laparoscopic versus open colorectal surgery for (A) general health, (B) physical functioning, (C) social functioning, and (D) bodily pain.
Figure 4.
Figure 4.
Forest plot of laparoscopic versus open colorectal surgery for (A) vitality, (B) Quality of life index (QLI), (C) physical component summary (PCS), and (D) mental component summary (MCS).
See this image and copyright information in PMC

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References

    1. Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019;16:713–32. - PubMed
    1. Jasperson KW, Tuohy TM, Neklason DW, et al. . Hereditary and familial colon cancer. Gastroenterology. 2010;138:2044–58. - PMC - PubMed
    1. Ligibel JA, Bohlke K, May AM, et al. . Exercise, diet, and weight management during cancer treatment: ASCO guideline. J Clin Oncol. 2022;40:2491–507. - PubMed
    1. Murphy N, Ward HA, Jenab M, et al. . Heterogeneity of colorectal cancer risk factors by anatomical subsite in 10 European countries: a multinational cohort study. Clin Gastroenterol Hepatol. 2019;17:1323–1331.e6. - PMC - PubMed
    1. Wyld L, Audisio RA, Poston GJ. The evolution of cancer surgery and future perspectives. Nat Rev Clin Oncol. 2015;12:115–24. - PubMed

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