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Review
. 2023 Sep 8;102(36):e34911.
doi: 10.1097/MD.0000000000034911.

Biosynthesis, structure and biological function of cholesterol glucoside in Helicobacter pylori: A review

Lanchi Zhang  1 , Jingri Xie  2
Affiliations
Review

Biosynthesis, structure and biological function of cholesterol glucoside in Helicobacter pylori: A review

Lanchi Zhang et al. Medicine (Baltimore). .

Abstract

Helicobacter pylori (H pylori) is a common pathogen, and about 50% of the world population have been infected with it, so the infection of H pylori has been an urgent public health problem worldwide. H pylori has evolved a variety of strategies to help itself colonize, adapt to the environment and proliferate. Cholesterol glucoside (CG), a characteristic substance in H pylori, is related to the membrane stability, morphology, inflammation induction and immune evasion of H pylori. Therefore, CG may be a new target to weaken the infection effect of H pylori. The biosynthesis process, structure and biological function of CG specific to H pylori, as well as anti-CG drugs are discussed and analyzed in this review, in order to explore whether the inhibition of CG synthesis can be an effective strategy to eradicate H pylori.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Structure of cholesterol glucoside (CG). (A) cholesterol-α-D-glucopyranoside (αCG), (B) cholesteryl-6’-O-tetradecanoyl-α-D-glucopyranoside (αCAG), (C) cholesteryl-6’-O-phosphatidyl-α-D-glucopyranoside (αCPG), Lipid = C 14:0, C16:0, C 18:1, C 19:0.
See this image and copyright information in PMC

References

    1. Leja M, Grinberga-Derica I, Bilgilier C, et al. Review: epidemiology of Helicobacter pylori infection. Helicobacter. 2019;24:e12635. - PubMed
    1. Malfertheiner P, Megraud F, O’Morain C, et al. Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 2007;56:772–81. - PMC - PubMed
    1. Malfertheiner P, Megraud F, O’Morain CA, et al. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017;66:6–30. - PubMed
    1. Sezgin O, Aydin MK, Özdemir AA, et al. Standard triple therapy in Helicobacter pylori eradication in Turkey: systematic evaluation and meta-analysis of 10-year studies. Turk J Gastroenterol. 2019;30:420–35. - PMC - PubMed
    1. Malfertheiner P, Megraud F, Rokkas T, et al. Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report [published online ahead of print August 8, 2022]. Gut. doi: 10.1136/gutjnl-2022-327745.