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Comparative Study
. 1986 Sep;22(3):343-5.
doi: 10.1111/j.1365-2125.1986.tb02897.x.

A simple method for determining acetylator phenotype using isoniazid

A Hutchings, P A Routledge
Comparative Study

A simple method for determining acetylator phenotype using isoniazid

A Hutchings et al. Br J Clin Pharmacol. 1986 Sep.

Abstract

A comparison was made between the results of acetylator phenotyping by isoniazid (INH) half-life measurements based on samples taken for 6 h after a single oral dose (200 mg), and by determination of the ratio of acetylisoniazid (Ac.INH) to isoniazid in the 3 h samples. In the 32 subjects, examined, there was complete agreement about classification of the subject as a fast (t1/2 less than 130 min; Ac.INH/INH greater than 1.5) or slow acetylator (t1/2 greater than 130 min; Ac.INH/INH less than 1.5). The single sample test appears to be as reliable as the more time-consuming isoniazid half-life method.

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