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Clinical Trial
. 1986 Sep;22(3):351-5.
doi: 10.1111/j.1365-2125.1986.tb02899.x.

Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate

J Caldwell, A H Staib, I A Cotgreave, M Siebert-Weigel
Clinical Trial

Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate

J Caldwell et al. Br J Clin Pharmacol. 1986 Sep.

Abstract

Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross-over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra-subject variation associated with the solubilizing agent used.

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